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anti-Hemochromatosis (HFE) Antibodies

The protein encoded by HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Additionally we are shipping HFE Proteins (15) and HFE Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HFE 3077 Q30201
HFE 29199 O35799
HFE 15216 P70387
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Top anti-HFE Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-HFE Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HFE antibody (Center) in Jurkat cell line lysates (35 µg/lane). HFE (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of HFE antibody (Center) (ABIN390457) in Jurkat cell line lysates (35 µg/lane). HFE (arrow) was detected using the purified polyclonal antibody. HFE Antibody (Center) (ABIN390457) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to HFE on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of HFE expression in transfected 293T cell line by HFE monoclonal antibody (M01), clone 1G12. Lane 1: HFE transfected lysate(40.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of HepG2 cells using HFE mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HFE Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysate WB Suggested Anti-HFE  Antibody Titration: 0.2-1 µg/mL  Positive Control: Hela cell lysate  There is BioGPS gene expression data showing that HFE is expressed in HeLa 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to HFE on HeLa cell. [antibody concentration 10 ug/ml] HFE monoclonal antibody (M01), clone 1G12. Western Blot analysis of HFE expression in A-431. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: HFE Antibody [NBP1-83250] - Staining of human rectum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ICC, IF, IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$551.83
Details

HFE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HFE Antibodies

  1. Human Monoclonal HFE Primary Antibody for IF, WB - ABIN395159 : Lehmann, Schuur, Warden, Hammond, Belbin, Kölsch, Lehmann, Wilcock, Brown, Kehoe, Morris, Barker, Coto, Alvarez, Deloukas, Mateo, Gwilliam, Combarros, Arias-Vásquez, Aulchenko, Ikram, Breteler, van Duijn, Oulhaj, Heun, Cortina-Borja, Morgan, Robson, Smith: Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. in Neurobiology of aging 2011 (PubMed)
    Show all 5 references for ABIN395159

  2. Human Polyclonal HFE Primary Antibody for IHC (p), WB - ABIN390457 : Valenti, Girelli, Valenti, Castagna, Como, Campostrini, Rametta, Dongiovanni, Messa, Fargion: HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients. in Clinical journal of the American Society of Nephrology : CJASN 2009 (PubMed)
    Show all 2 references for ABIN390457

  3. Human Monoclonal HFE Primary Antibody for ICC, ELISA - ABIN969192 : Hosgood, Menashe, He, Chanock, Lan: PTEN identified as important risk factor of chronic obstructive pulmonary disease. in Respiratory medicine 2009 (PubMed)
    Show all 2 references for ABIN969192

  4. Human Polyclonal HFE Primary Antibody for EIA, WB - ABIN453091 : Won, Jeong, Chung, Lee, Hwang, Kim, Lee, Kim, Park, Lee, Kim: Hepatic iron, serum ferritin, HFE mutation, and hepatic fibrosis in chronic hepatitis C. in Intervirology 2009 (PubMed)
    Show all 2 references for ABIN453091

  5. Human Polyclonal HFE Primary Antibody for IHC, IHC (p) - ABIN4317233 : Lenarduzzi, Hui, Yue, Ito, Shi, Williams, Bruce, Sakemura-Nakatsugawa, Xu, Schimmer, Liu: Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. in PLoS ONE 2013 (PubMed)

  6. Cow (Bovine) Polyclonal HFE Primary Antibody for IHC, WB - ABIN2781800 : Gleeson, Evans, Bradley, Jones, Peck, Dube, Rigby, Dalton: HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. in The American journal of gastroenterology 2006 (PubMed)

More Antibodies against HFE Interaction Partners

Human Hemochromatosis (HFE) interaction partners

  1. In this study, HFE p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02).

  2. Statistically significant differences were observed for genotype distribution of C282Y and H63D between the general population and the patients diagnosed with hereditary hemochromatosis.

  3. There are no relationship between these indexes and HFE gene C282Y mutation and either nonalcoholic fatty liver disease as a complication of diabetes.

  4. H63D HFE genetic carriers presented higher blood iron than wild-type probands.

  5. Data suggest that hereditary hemochromatosis (HH) due to mutations in HFE may be relatively asymptomatic in childhood as illustrated by diagnosis of HH in 10-year-old twin boys during investigation of cause of short stature/growth retardation in one of the boys; genetic testing revealed C282Y/H63D compound heterozygosity in HFE GENE. [CASE REPORT]

  6. Results suggest that HFE H63D polymorphism could represent a disease-modifying gene in frontotemporal lobar degeneration, fostering iron deposition in the basal ganglia

  7. performed molecular dynamics simulation for 40 ns to see the effect of GdmCl on the structural stability of HFE. A well defined correlation was established between in vitro and in silico studies

  8. Hypothesized that the C282Y allele of hemochromatosis protein was an adaptation of migrating farmers from the Middle East to the novel environment of chilly and damp (show AMPH Antibodies) Europe; studied C282Y allele frequencies & climatic data; findings indicate that geographic cline for C282Y frequency in Europe increases as average temperatures decrease below 16 degrees C.

  9. Study shows that HFE is expressed in choriocarcinoma tumor cells as well as within cytotrophoblastic elements of cystic trophoblastic tumor and intermediate trophoblast of an exaggerated placenta site supporting HFE as a viable marker for trophoblast progenitors.

  10. Report risk factors for insulin (show INS Antibodies) resistance, metabolic syndrome and diabetes mellitus in HFE C282Y homozygotes.

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  2. Single Hjv (show HFE2 Antibodies)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Antibodies)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Antibodies) regulate hepcidin (show HAMP Antibodies) via the same pathway.

  3. Results show that HFE requires HJV (show HFE2 Antibodies) to activate downstream signal transduction pathways for hepcidin (show HAMP Antibodies) regulation.

  4. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  5. results provide evidence that HFE induces hepcidin (show HAMP Antibodies) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Antibodies) to stabilize ALK3 (show BMPR1A Antibodies) protein and increase ALK3 (show BMPR1A Antibodies) expression at the cell surface.

  6. These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Antibodies) can independently regulate hepcidin (show HAMP Antibodies).

  7. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  8. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  9. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (show BIRC5 Antibodies) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

  10. Findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis.

HFE Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Gene names and symbols associated with anti-Hemochromatosis (HFE) Antibodies

  • hemochromatosis (HFE) antibody
  • hemochromatosis (Hfe) antibody
  • HFE1 antibody
  • HH antibody
  • HLA-H antibody
  • MR2 antibody
  • MVCD7 antibody
  • TFQTL2 antibody

Protein level used designations for anti-Hemochromatosis (HFE) Antibodies

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

GENE ID SPECIES
3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
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