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Hemochromatosis Proteins (HFE)

The protein encoded by HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Additionally we are shipping HFE Antibodies (72) and HFE Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HFE 3077 Q30201
HFE 29199 O35799
HFE 15216 P70387
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Top HFE Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rhinoceros His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Diceros bicornis His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Ceratotherium simum His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details

HFE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,
,

Top referenced HFE Proteins

  1. Human HFE Protein expressed in Escherichia coli (E. coli) - ABIN1098722 : Feder, Penny, Irrinki, Lee, Lebrón, Watson, Tsuchihashi, Sigal, Bjorkman, Schatzman: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for ABIN1098722

More Proteins for Hemochromatosis (HFE) Interaction Partners

Human Hemochromatosis (HFE) interaction partners

  1. H63D HFE genetic carriers presented higher blood iron than wild-type probands.

  2. Data suggest that hereditary hemochromatosis (HH) due to mutations in HFE may be relatively asymptomatic in childhood as illustrated by diagnosis of HH in 10-year-old twin boys during investigation of cause of short stature/growth retardation in one of the boys; genetic testing revealed C282Y/H63D compound heterozygosity in HFE GENE. [CASE REPORT]

  3. Results suggest that HFE H63D polymorphism could represent a disease-modifying gene in frontotemporal lobar degeneration, fostering iron deposition in the basal ganglia

  4. performed molecular dynamics simulation for 40 ns to see the effect of GdmCl on the structural stability of HFE. A well defined correlation was established between in vitro and in silico studies

  5. Hypothesized that the C282Y allele of hemochromatosis protein was an adaptation of migrating farmers from the Middle East to the novel environment of chilly and damp (show AMPH Proteins) Europe; studied C282Y allele frequencies & climatic data; findings indicate that geographic cline for C282Y frequency in Europe increases as average temperatures decrease below 16 degrees C.

  6. Study shows that HFE is expressed in choriocarcinoma tumor cells as well as within cytotrophoblastic elements of cystic trophoblastic tumor and intermediate trophoblast of an exaggerated placenta site supporting HFE as a viable marker for trophoblast progenitors.

  7. Report risk factors for insulin (show INS Proteins) resistance, metabolic syndrome and diabetes mellitus in HFE C282Y homozygotes.

  8. genetic association study in French population: Data suggest that 80% of high-performing, high-endurance athletes (those who won international competitions in rowing, Nordic skiing, and judo) display heterozygosity for mutations in one allele of HFE.

  9. Total iron binding capacity was strongly associated with variants in and near the TF gene, and with variants in HFE gene in premenopausal women of European descent.

  10. HFE gene expression level of iron deficiency anemia patients was significantly higher than other groups.

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  2. Single Hjv (show HFE2 Proteins)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Proteins)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Proteins) regulate hepcidin (show HAMP Proteins) via the same pathway.

  3. Results show that HFE requires HJV (show HFE2 Proteins) to activate downstream signal transduction pathways for hepcidin (show HAMP Proteins) regulation.

  4. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  5. results provide evidence that HFE induces hepcidin (show HAMP Proteins) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Proteins) to stabilize ALK3 (show BMPR1A Proteins) protein and increase ALK3 (show BMPR1A Proteins) expression at the cell surface.

  6. These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Proteins) can independently regulate hepcidin (show HAMP Proteins).

  7. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  8. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  9. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (show BIRC5 Proteins) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

  10. Findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis.

HFE Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Gene names and symbols associated with Hemochromatosis Proteins (HFE)

  • hemochromatosis (HFE)
  • hemochromatosis (Hfe)
  • HFE1 protein
  • HH protein
  • HLA-H protein
  • MR2 protein
  • MVCD7 protein
  • TFQTL2 protein

Protein level used designations for Hemochromatosis Proteins (HFE)

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

GENE ID SPECIES
3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
Selected quality suppliers for HFE Proteins (HFE)
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