You are viewing an incomplete version of our website. Please click to reload the website as full version.

Hemochromatosis Proteins (HFE)

The protein encoded by HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Additionally we are shipping HFE Antibodies (72) and HFE Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HFE 3077 Q30201
HFE 29199 O35799
HFE 15216 P70387
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top HFE Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Ceratotherium simum His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Rhinoceros His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Diceros bicornis His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details

HFE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,
,

Top referenced HFE Proteins

  1. Human HFE Protein expressed in Escherichia coli (E. coli) - ABIN1098722 : Feder, Penny, Irrinki, Lee, Lebrón, Watson, Tsuchihashi, Sigal, Bjorkman, Schatzman: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for ABIN1098722

More Proteins for Hemochromatosis (HFE) Interaction Partners

Human Hemochromatosis (HFE) interaction partners

  1. Total iron binding capacity was strongly associated with variants in and near the TF gene, and with variants in HFE gene in premenopausal women of European descent.

  2. HFE gene expression level of iron deficiency anemia patients was significantly higher than other groups.

  3. The HFE- and non-HFE hemochromatosis syndromes represent the paradigms of genetic iron overload.

  4. results indicate the association between the C282Y/Q283P compound heterozygous genotype in trans and the development of iron overload; this is the second case report on the HFE Q283P mutation in hemochromtosis

  5. study provides evidence that the complex allele HFE-c.[187C>G;340+4T>C] has a role, as genetic predisposition factor, on iron overload in the Sao Miguel population

  6. Its polymorphism does not influence ALS phenotype and survival.

  7. iron dysregulation associated with HFE allelic variants may play an important role in increasing susceptibility to environmental exposures, leading to recurring injury and fibrosis in idiopathic pulmonary fibrosis

  8. this review describes the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload. [review]

  9. this analysis provided strong evidence that the HFE H63D polymorphism may play a critical role in the increased aggressiveness of hepatocellular carcinoma and pancreatic cancer.

  10. haplotype analysis of common HFE mutations in the Portuguese population, is reported.

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  2. Single Hjv (show HFE2 Proteins)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Proteins)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Proteins) regulate hepcidin (show HAMP Proteins) via the same pathway.

  3. Results show that HFE requires HJV (show HFE2 Proteins) to activate downstream signal transduction pathways for hepcidin (show HAMP Proteins) regulation.

  4. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  5. results provide evidence that HFE induces hepcidin (show HAMP Proteins) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Proteins) to stabilize ALK3 (show BMPR1A Proteins) protein and increase ALK3 (show BMPR1A Proteins) expression at the cell surface.

  6. These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Proteins) can independently regulate hepcidin (show HAMP Proteins).

  7. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  8. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  9. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (show BIRC5 Proteins) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

  10. Findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis.

HFE Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Gene names and symbols associated with Hemochromatosis Proteins (HFE)

  • hemochromatosis (HFE)
  • hemochromatosis (Hfe)
  • HFE1 protein
  • HH protein
  • HLA-H protein
  • MR2 protein
  • MVCD7 protein
  • TFQTL2 protein

Protein level used designations for Hemochromatosis Proteins (HFE)

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

GENE ID SPECIES
3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
Selected quality suppliers for HFE Proteins (HFE)
Did you look for something else?