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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Proteins (34) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.
Showing 10 out of 194 products:
Human Polyclonal HAVCR2 Primary Antibody for WB - ABIN1881402
Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer. in Cancer immunology, immunotherapy : CII 2010
Show all 5 references for ABIN1881402
Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for FACS - ABIN2476821
Warner: Tobacco industry scientific advisors: serving society or selling cigarettes? in American journal of public health 1991
Show all 3 references for ABIN2476821
Human Polyclonal HAVCR2 Primary Antibody for ELISA, WB - ABIN269847
Meyers, Sabatos, Chakravarti, Kuchroo: The TIM gene family regulates autoimmune and allergic diseases. in Trends in molecular medicine 2005
Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for IHC (fro), FACS - ABIN955215
Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003
Human Polyclonal HAVCR2 Primary Antibody for WB - ABIN2782255
Nuchnoi, Ohashi, Kimura, Hananantachai, Naka, Krudsood, Looareesuwan, Tokunaga, Patarapotikul: Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. in Annals of human genetics 2008
The Tim-3/Gal-9 (show LGALS9 Antibodies) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Hepatitis B virus surface antigen stimulation of human, monocyte-derived dendritic cells increases expression of Tim-3.
miR (show MLXIP Antibodies)-330-5p has a strong inhibitory effect on TIM-3 expression in acute myeloma leukaemia cell line
Data show there was a negative correlation between soluble T cell immunoglobulin mucin (show SLC13A2 Antibodies) molecule 3 (sTim-3) and interferon-gamma (IFN-gamma (show IFNG Antibodies)) as well as between IFN-gamma (show IFNG Antibodies) and interleukin-4 (IL-4 (show IL4 Antibodies)), while sTim-3 and IL-4 (show IL4 Antibodies) were positively correlated.
Data suggest that PD-1/PDCD1 (programmed cell death protein 1 (show PDCD1 Antibodies)) and Tim-3/HAVCR2 (hepatitis A virus cellular receptor 2) operate within the functional immune-modulatory network to promote Th2-(type-2 helper T cell-)mediated immunity at the maternal-fetal interface.
Reduction of Tim-3(+) Treg cells (Tregs) in osteoarthritis patients resulted in less IL-10 (show IL10 Antibodies)-producing Tregs.
findings support the use of Tim-3-Tim-3L blockade together with PD-1 (show PDCD1 Antibodies)-PD-L1 (show CD274 Antibodies) blockade to reverse tumor-induced T-cell exhaustion/dysfunction in patients with colorectal cancer.
Tim-3 may be used as a novel target for increasing immune responses in RCC (show XRCC1 Antibodies) tumor microenvironment.
Diffuse large B-cell lymphoma patients have high expression level of PD-1 (show PDCD1 Antibodies) and TIM-3, which are related to DLBCL staging. PD-1 (show PDCD1 Antibodies) and TIM-3 expression levels are also related to the efficiency of chemotherapy.
The Gal-9 (show LGALS9 Antibodies)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
These data indicate that Tim-3 expression in NK cells can function as a prognostic biomarker in human lung adenocarcinoma and support that Tim-3 could be a new target for an immunotherapeutic strategy.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 Antibodies)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Antibodies)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A Antibodies)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 Antibodies) binds TIM3 on the surface of polarized Th1 (show HAND1 Antibodies) cells to induce Th1 (show HAND1 Antibodies) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Antibodies) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Antibodies) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Antibodies)-dependent manner.
These data identify an IL-27 (show IL27 Antibodies)/NFIL3 (show NFIL3 Antibodies) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 Antibodies) and T-cell dysfunction.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog