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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Proteins (29) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.
Showing 10 out of 155 products:
Human Polyclonal HAVCR2 Primary Antibody for WB - ABIN1881402
Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer. in Cancer immunology, immunotherapy : CII 2010
Show all 5 references for ABIN1881402
Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for FACS - ABIN2476821
Warner: Tobacco industry scientific advisors: serving society or selling cigarettes? in American journal of public health 1991
Show all 3 references for ABIN2476821
Human Polyclonal HAVCR2 Primary Antibody for ELISA, WB - ABIN185571
Meyers, Sabatos, Chakravarti, Kuchroo: The TIM gene family regulates autoimmune and allergic diseases. in Trends in molecular medicine 2005
Human Polyclonal HAVCR2 Primary Antibody for WB - ABIN2782255
Nuchnoi, Ohashi, Kimura, Hananantachai, Naka, Krudsood, Looareesuwan, Tokunaga, Patarapotikul: Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. in Annals of human genetics 2008
Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for IHC (fro), FACS - ABIN955215
Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003
The Tim-3/Gal-9 (show LGALS9 Antibodies) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Tim-3 in primary leukocytes, both healthy and malignant AML cells, displays moderate properties of an inflammatory receptor with additional growth factor (mTOR activation) and pro-angiogenic (VEGF release) activities
Tim-3 played an important role in the development and progression of gastric cancer, and it could be used as an independent prognostic factor for gastric cancer patients.
an abnormal Tim-3/Gal-9 (show LGALS9 Antibodies) pathway was able to facilitate the development of preeclampsia.
sTim-3 was involved in the development of sepsis. The homeostasis-promoting role of the Tim-3 on the monocytes was disrupted, while the inhibitory role of sTim-3 emerged during sepsis-induced immunosuppression.
decreased serum TIM-1 (show ARHGEF5 Antibodies) and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of systemic lupus erythematosus.
Results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC (show CALR Antibodies) patients.
TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3 (show CD3 Antibodies)/CD28 (show CD28 Antibodies) co-stimulation.
Tim-3 might participate in the tumorgenesis of colon cancer and Tim-3 expression might be a potential independent prognostic factor for patients with colorectal cancer.
TIM-3 polymorphism is associated with increased susceptibility to osteoarthritis.
TIM-3 and its ligand, galectin-9 (Gal-9 (show LGALS9 Antibodies)), constitute an autocrine loop critical for leukemic stem cells self-renewal and development of human acute myeloid leukemia (show BCL11A Antibodies).
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Antibodies) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Antibodies) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Antibodies)-dependent manner.
These data identify an IL-27 (show IL27 Antibodies)/NFIL3 (show NFIL3 Antibodies) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 Antibodies) and T-cell dysfunction.
CD4 (show CD4 Antibodies)+ T cell-dependent "negative" TIM-3 costimulation is essential for hepatic homeostasis and resistance against IR stress in OLTs
In DSS (show PMP22 Antibodies) colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Tim-3 effect on macrophage response may be TLR4 (show TLR4 Antibodies) dependent.
These data suggest that Tim-3 and IFN-gamma (show IFNG Antibodies) may play a regulatory role in T. gondii-infected pregnant mouse model.
Gal-9 (show LGALS9 Antibodies), a natural TIM-3 ligand, was produced primarily by and released from ischemia-reperfusion-stressed hepatocytes, both in vivo and in vitro.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog