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anti-Hephaestin (HEPH) Antibodies

The protein encoded by HEPH is similar to an iron transport protein found in mouse. Additionally we are shipping Hephaestin Kits (9) and Hephaestin Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HEPH 15203 Q9Z0Z4
HEPH 117240 Q920H8
HEPH 9843 Q9BQS7
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Top anti-Hephaestin Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-HEPH Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:3... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB HEPH monoclonal antibody (M01), clone 2D3 Western Blot analysis of HEP... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated WB HEPH antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Mouse Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 8 to 10 Days
$566.50
Details
Human Mouse Un-conjugated ELISA, WB HEPH monoclonal antibody (M01), clone 2D3 Western Blot analysis of HEP... Detection limit for recombinant GST tagged HEPH is approximately 0.3ng... 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

HEPH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , ,

Rat (Rattus) , , , ,

Human , , , ,
,

Top referenced anti-Hephaestin Antibodies

  1. Human Monoclonal Hephaestin Primary Antibody for WB - ABIN395505 : Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. in Molecular human reproduction 2010 (PubMed)
    Show all 5 references for ABIN395505

  2. Dog (Canine) Polyclonal Hephaestin Primary Antibody for WB - ABIN2782835 : Han, Kim: Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells. in Journal of cellular biochemistry 2007 (PubMed)

More Antibodies against Hephaestin Interaction Partners

Mouse (Murine) Hephaestin (HEPH) interaction partners

  1. In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.

  2. The multicopper ferroxidase (show A2BP1 Antibodies) hephaestin enhances intestinal iron absorption in mice.

  3. Data (including data from studies in knockout mice) suggest that hephaestin and ceruloplasmin (show CP Antibodies) play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis.

  4. Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina.

  5. results show that Heph is expressed by oligodendrocytes and plays an important role in iron efflux from these cells.

  6. Hephaestin and Ireg1 (show SLC40A1 Antibodies) expression respond to systemic rather than local signals of iron status.

  7. Hephaestin has both amine oxidase (show MAOA Antibodies) and ferroxidase (show CP Antibodies) activity primary intestinal enterocytes and may facilitate iron export from intestinal enterocytes; also activity and structural studies of truncated Heph in sla mice

  8. Ceruloplasmin (show CP Antibodies) ane hephaestin are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration.

  9. CDX2 (show CDX2 Antibodies) expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 (show CDX2 Antibodies) and HEPH and enhanced iron export.

  10. Copper is required for the proper processing and/or stability of hephaestin.

Human Hephaestin (HEPH) interaction partners

  1. This review describes function of hephaestin as ferroxidase (show CP Antibodies) is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein.

  2. Iron efflux from human brain microvasculature endothelial cells ferroportin (show SLC40A1 Antibodies) requires the action of an exocytoplasmic ferroxidase (show CP Antibodies) which can be either endogenous hephaestin or extracellular ceruloplasmin (show CP Antibodies).

  3. Heph is active in placenta but may not play a key role in placental iron transport.

  4. These results support the hypothesis that hephaestin is involved in iron mobilization of iron from the intestine to circulation.

  5. In contrast to ceruloplasmin (show CP Antibodies), hephaestin was incapable of direct oxidation of adrenaline and dopamine implying a difference in biological substrate specificities between these two homologous ferroxidases.

  6. Hephaestin is expressed in enterocytes, in the antral portion of the stomach, in the myenteric and submucous plexi, and in pancreatic beta-cells.

  7. The gene structure, spanning approximately 100 kb, was assembled from the cDNA clones and the chromosome X genomic sequence data. Modelling supports its role as a membrane-tethered ferroxidase (show CP Antibodies).

  8. The hephaestin protein mRNA expression is not significantly altered by variations in iron homeostasis. The effect of phlebotomy-induced erythropoiesis did not alter either gene transcript mRNA expression.

  9. Reombinant hephaestin was shown to have both multicopper oxidase and ferroxidase (show CP Antibodies) activity.

  10. Results suggest the possibility that FPN-1 (show SLC40A1 Antibodies) might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell.

Hephaestin (HEPH) Antigen Profile

Protein Summary

The protein encoded by this gene is similar to an iron transport protein found in mouse. The mouse protein is similar to ceruloplasmin, a serum multi-copper ferroxidase, and is thought to be a membrane-bound protein responsible for transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system. In mouse, defects in this gene can lead to severe microcytic anemia. Three transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with anti-Hephaestin (HEPH) Antibodies

  • hephaestin (HEPH) antibody
  • hephaestin (heph) antibody
  • hephaestin (Heph) antibody
  • C130006F04Rik antibody
  • CPL antibody
  • HEPH antibody
  • mKIAA0698 antibody
  • sla antibody

Protein level used designations for anti-Hephaestin (HEPH) Antibodies

hephaestin , hephaestin-like , haphaestin , sex linked anemia

GENE ID SPECIES
422168 Gallus gallus
100065379 Equus caballus
100359242 Oryctolagus cuniculus
100400146 Callithrix jacchus
100431753 Pongo abelii
100550447 Meleagris gallopavo
100554907 Anolis carolinensis
100597576 Nomascus leucogenys
15203 Mus musculus
117240 Rattus norvegicus
9843 Homo sapiens
491926 Canis lupus familiaris
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