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anti-Histocompatibility (Minor) 13 (HM13) Antibodies

The protein encoded by HM13, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. Additionally we are shipping Histocompatibility (Minor) 13 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HM13 81502 Q8TCT9
HM13 14950 Q9D8V0
HM13    
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Top anti-Histocompatibility (Minor) 13 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB HM13 Antibody (C-term) (ABIN658313) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the HM13 antibody detected the HM13 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

HM13 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,


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Top referenced anti-Histocompatibility (Minor) 13 Antibodies

  1. Human Polyclonal HM13 Primary Antibody for WB - ABIN658313 : Sato, Nyborg, Iwata, Diehl, Saido, Golde, Wolfe: Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. in Biochemistry 2006 (PubMed)
    Show all 2 references for ABIN658313

More Antibodies against Histocompatibility (Minor) 13 Interaction Partners

Human Histocompatibility (Minor) 13 (HM13) interaction partners

  1. structure of human SPP (show SPEB Antibodies) [SPP (show SPEB Antibodies)]

  2. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP (show SPEB Antibodies)]

  3. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1 (show IMPA1 Antibodies)]

  4. widespread expression of SPP (show SPEB Antibodies) in many tissues

  5. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

  6. IMP1 (show IMPA1 Antibodies) is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2 (show PSEN2 Antibodies).

  7. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy.

  8. SPP (show SPEB Antibodies), SPPL2a (show SPPL2A Antibodies), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  9. data implicate SPP (show SPEB Antibodies) in the US2 (show USH2A Antibodies) pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum

  10. Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP (show SPEB Antibodies) are remarkably similar to gamma-secretase.

Mouse (Murine) Histocompatibility (Minor) 13 (HM13) interaction partners

  1. silencing of SPP and its family member SPPL2a led to a general reduction of surface peptide-MHC-I complexes, underlining the involvement of these enzymes in Ag processing and presentation.

  2. structural analysis of H13 peptides lacking MHC binding anchor motifs determines self-nonself discrimination

  3. widespread expression of SPP (show SPEB Antibodies) in many tissues; a distinct pattern of expression in the mature murine brain and during development indicates that SPP (show SPEB Antibodies) plays an important role in the establishment and maintenance of the nervous system

  4. A single minor histocompatibility antigen mismatch at the polymorphic H13 allele plays a role in chronic allograft rejection of solid organs such as obliterative airway disease development following murine tracheal transplantation.

  5. new splice variant,signal peptide peptidase (SPP)beta, with an additional in-frame exon inserted between exons 11 and 12 of SPPalpha

  6. Results show that two genetic systems show that alleles lacking methylation generate truncated H13 transcripts that undergo internal polyadenylation.

Histocompatibility (Minor) 13 (HM13) Antigen Profile

Protein Summary

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene names and symbols associated with HM13

  • histocompatibility (minor) 13 (hm13) antibody
  • histocompatibility (minor) 13 (HM13) antibody
  • histocompatibility 13 (H13) antibody
  • 1200006O09Rik antibody
  • 4930443L17Rik antibody
  • 5031424B04Rik antibody
  • AV020344 antibody
  • cb228 antibody
  • dJ324O17.1 antibody
  • H-13 antibody
  • h13 antibody
  • Hm13 antibody
  • IMP1 antibody
  • IMPAS antibody
  • IMPAS-1 antibody
  • MGC68919 antibody
  • MSTP086 antibody
  • PSENL3 antibody
  • PSL3 antibody
  • Spp antibody
  • SPPL1 antibody
  • wu:fc11a06 antibody
  • zgc:56660 antibody
  • zgc:86862 antibody

Protein level used designations for HM13

histocompatibility 13 , signal peptide peptidase , intramembrane aspartyl protease , histocompatibility (minor) 13 , minor histocompatibility antigen 13 , minor histocompatibility antigen H13 , minor histocompatibility antigen H13-like , IMP-1 , hIMP1 , intramembrane protease 1 , presenilin-like protein 3 , signal peptide peptidase beta , signal peptide peptidase like 1 , presenilin-like aspartyl protease

GENE ID SPECIES
259190 Danio rerio
380568 Xenopus laevis
469911 Pan troglodytes
512534 Bos taurus
608355 Canis lupus familiaris
713216 Macaca mulatta
100010776 Monodelphis domestica
100053502 Equus caballus
100124822 Xenopus (Silurana) tropicalis
100348554 Oryctolagus cuniculus
100386877 Callithrix jacchus
100447672 Pongo abelii
100582871 Nomascus leucogenys
81502 Homo sapiens
14950 Mus musculus
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