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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping HIST1H1C Proteins (5) and HIST1H1C Kits (1) and many more products for this protein.
Showing 10 out of 38 products:
Cow (Bovine) Polyclonal HIST1H1C Primary Antibody for ChIP, WB - ABIN2782497
Kim, Choi, Heo, Kim, Levens, Kohno, Johnson, Brock, An: Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription. in The Journal of biological chemistry 2008
Human Polyclonal HIST1H1C Primary Antibody for WB - ABIN653110
Mayya, Lundgren, Hwang, Rezaul, Wu, Eng, Rodionov, Han: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. in Science signaling 2009
BRG1 (show SMARCA4 Antibodies) participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.
Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells.
Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 (show KRT26 Antibodies) modifications are essential for proper cell cycle progression.
H1.2 interacts with Cul4A (show CUL4A Antibodies) and PAF1 (show PEX2 Antibodies) to activate developmental regulatory genes.
H1.2 is less abundant than other histone H1 (show H1F0 Antibodies) variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 (show H1F0 Antibodies) variants and tend to be repressed.
Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
These data suggest that p53 (show TP53 Antibodies) acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53 (show TP53 Antibodies)-dependent DNA damage response pathways.
confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (show CDK1 Antibodies) (CDK (show CDK4 Antibodies)) consensus motif
The binding of histone H1 (show H1F0 Antibodies) to a general amyloid-like motif indicates that histone H1 (show H1F0 Antibodies) may play an important common role in diseases associated with amyloid-like fibrils.
Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak (show BAK1 Antibodies) in mitochondria.
Histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors.
These results integrate the localization of an understudied type of chromatin proteins, namely the H1 variants, into the epigenome map of mouse ESCs (show NR2E3 Antibodies).
The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 (show H1F0 Antibodies) and H1c.
The amount of the linker histone H1c is strongly reduced in nuclear extracts of SCA7 (show ATXN7 Antibodies) retinas and that the cellular distribution of H1c is particularly altered in the facultative heterochromatin compartment.
The modular pattern of DNA methylation (show HELLS Antibodies) in the Ig heavy chain locus and histone modifications appears to be determined by at least 2 factors: the B-cell-specific transcription factor Pax5 (show PAX5 Antibodies) and linker histone H1 (show H1F0 Antibodies).
These observations reveal a mode of p53 (show TP53 Antibodies) regulation mediated by CHD8 (show CHD8 Antibodies), which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (show TP53 Antibodies) function through recruitment of histone H1 (show H1F0 Antibodies).
H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
, histone H1.1
, histone H1.2
, histone H1d
, histone 1, H1c
, histone H1.11L
, H1 histone family, member 2
, histone H1c
, histone H1s-1
, H1 VAR.1
, histone H1
, H1 histone family, member 4
, Histone 1d
, histone H1.4