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anti-Holocytochrome C Synthase (HCCS) Antibodies

The protein encoded by HCCS is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Additionally we are shipping Holocytochrome C Synthase Kits (13) and Holocytochrome C Synthase Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HCCS 3052 P53701
HCCS 317444  
HCCS 15159 P53702
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Top anti-Holocytochrome C Synthase Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of HCCS Antibody (Center) (ABIN653839) in WiDr cell line lysates (35 µg/lane). HCCS (arrow) was detected using the purified polyclonal antibody. Western blot analysis of HCCS Antibody (Center) (ABIN653839) in mouse heart tissue lysates (35 µg/lane). HCCS (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded colon carcinoma reacted with HCCS / CCHL Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of HCCS / CCHL Antibody (Center) in mouse heart tissue lysates (35ug/lane). HCCS (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HeLa/HepG2/COLO cells, using Cytochrome c-type Heme Lyase Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using Cytochrome c-type Heme Lyase Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HCCS AntibodyTitration: 1.0 µg/mL  Positive Control: HepG2 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HCCS AntibodyTitration: 1.0 µg/mL  Positive Control: U937 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of HCCS staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of HCCS staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IP, WB   100 μg Log in to see 8 to 10 Days
$771.83
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details

HCCS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Holocytochrome C Synthase Antibodies

  1. Human Polyclonal HCCS Primary Antibody for IHC (p), WB - ABIN952686 : Prakash, Cormier, McCall, Garcia, Sierra, Haupt, Zoghbi, Van Den Veyver: Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome. in Human molecular genetics 2002 (PubMed)
    Show all 3 references for ABIN952686

  2. Human Polyclonal HCCS Primary Antibody for IHC (p), WB - ABIN653839 : Need, Attix, McEvoy, Cirulli, Linney, Hunt, Ge, Heinzen, Maia, Shianna, Weale, Cherkas, Clement, Spector, Gibson, Goldstein: A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. in Human molecular genetics 2009 (PubMed)
    Show all 2 references for ABIN653839

  3. Human Polyclonal HCCS Primary Antibody for IF, IHC - ABIN1534309 : Schaefer, Ballabio, Zoghbi: Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS). in Genomics 1997 (PubMed)

More Antibodies against Holocytochrome C Synthase Interaction Partners

Human Holocytochrome C Synthase (HCCS) interaction partners

  1. cysteines and histidine of the heme attachment site, Cys (show DNAJC5 Antibodies)-XX-Cys (show DNAJC5 Antibodies)-His play a key role in mitochondrial holocytochrome c synthase

  2. These data indicate that heme contacts mediated by residues within these domains modulate the dynamics of heme binding and contribute to the stability of the HCCS-heme-cytochrome c (show CYCS Antibodies) steady state ternary complex.

  3. Identification of a deletion in two patients, including HCCS, leads to the diagnosis of microphthalmia with linear skin defects syndrome

  4. Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c (show CYCS Antibodies) revealed the fundamental steps of heme attachment and maturation.

  5. Through the study of genetically engineered mice, the loss of HCCS is demonstrated to cause the male lethality of microphthalmia with linear skin defects (MLS) syndrome.

  6. mutant proteins (R217C and Delta 197-268) were unable to complement a Saccharomyces cerevisiae mutant deficient for the HCCS orthologue Cyc3p, in contrast to wild-type HCCS

  7. Missense mutation p.E159K of HCCS, leading to loss-of-function of encoded holocytochrome c-type synthase, in female with microphthalmia of both eyes and bilateral sclerocornea may suggest HCCS as candidate for severe ocular manifestations.

Mouse (Murine) Holocytochrome C Synthase (HCCS) interaction partners

  1. Analysis of Mid1 (show MID1 Antibodies), Hccs, Arhgap6 (show ARHGAP6 Antibodies), and Msl3l1 (show MSL3 Antibodies) in X-linked polydactyly (Xpl) and Patchy-fur (Paf (show KIAA0101 Antibodies)) mutant mice

Holocytochrome C Synthase (HCCS) Antigen Profile

Protein Summary

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with HCCS

  • holocytochrome c synthase (hccs) antibody
  • cytochrome c heme-lyase (cchl) antibody
  • holocytochrome c synthase (HCCS) antibody
  • holocytochrome c synthase (Hccs) antibody
  • holocytochrome c synthase-like (LOC100356413) antibody
  • holocytochrome c synthetase (Hccs) antibody
  • CCHL antibody
  • DDBDRAFT_0217711 antibody
  • DDBDRAFT_0266707 antibody
  • DDB_0217711 antibody
  • DDB_0266707 antibody
  • hccsb antibody
  • id:ibd1278 antibody
  • MCOPS7 antibody
  • RGD1563855 antibody
  • wu:fb18h01 antibody
  • wu:fc64e12 antibody
  • wu:fi43e01 antibody

Protein level used designations for HCCS

cytochrome c-type heme lyase , holocytochrome c synthetase b , holocytochrome c synthase (cytochrome c heme-lyase) , holocytochrome c synthase , cytochrome c heme-lyase , holocytochrome c-type synthase , holocytochrome c synthetase , CCHL

GENE ID SPECIES
58016 Danio rerio
448226 Xenopus (Silurana) tropicalis
8620147 Dictyostelium discoideum AX4
3052 Homo sapiens
317444 Rattus norvegicus
506250 Bos taurus
424482 Gallus gallus
480834 Canis lupus familiaris
100356413 Oryctolagus cuniculus
15159 Mus musculus
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