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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA4 Proteins (8) and many more products for this protein.
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Dog (Canine) Polyclonal HOXA4 Primary Antibody for EIA, WB - ABIN498071
Klausen, Leung, Auersperg: Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin. in Molecular cancer research : MCR 2009
HOXA4 increases short-term repopulation to higher levels than HOXB4 (show HOXB4 Antibodies), which may involve Notch (show NOTCH1 Antibodies) signaling to induce self-renewal of primitive hematopoietic cells
The NK AML (show RUNX1 Antibodies) patients with NPM1 (show NPM1 Antibodies) mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 (show HOXA5 Antibodies) and MEIS1 (show MEIS1 Antibodies) compared with the NPM1 (show NPM1 Antibodies) wildtype patients.
promoter hypermethylation of HOXA4 gene could be an epigenetic mechanism mediating IM resistance in CML patients.
HOXA4 showed nuclear & perinuclear staining in endothelial & smooth muscle cells in aorta. Spatial variation in expression in human aortas persisted into adulthood. Downregulation of HOXA4 expression was associated with abdominal aortic aneurysm.
Studies suggest that HOXA4, HOXA5 (show HOXA5 Antibodies) and HOXB4 (show HOXB4 Antibodies) provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer.
Results confirm that HOXA4 inhibits cell motility, show that it suppresses cell spreading and filopodia formation while enhancing cell-cell adhesion, and suggest a role for beta1 integrin in mediating these changes.
upregulated significantly in acute myeloid leukemia (show BCL11A Antibodies) patients with a white blood cell count higher than 30 x 10(9)/L cells.
aberrant DNA methylation (show HELLS Antibodies) may have a major role in the control of HOXA4 gene expression in chronic lymphocytic leukemia
analysis of the role of deregulated PcG genes in acute myeloid leukemia (show BCL11A Antibodies), and the downstream PcG targets HOXA4, HOXA9 (show HOXA9 Antibodies) and MEIS1 (show MEIS1 Antibodies)
combination of low HOXA4 and low MEIS1 (show MEIS1 Antibodies) gene expression is a favourable predictor for outcome in all AML (show RUNX1 Antibodies) patients and that the expression levels are governed by the methylation state of these genes.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
homeobox protein Hox-A4
, homeo box A4
, homeobox A4
, homeobox protein XlHbox4b
, Homeobox gene A4
, homeobox protein R2
, Dfd-like protein
, Hox-1.4-like protein
, homeobox protein Hox-1.4
, homeobox protein Hox-1D
, homeobox protein MH-3
, Homeobox protein Hox-A4