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Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Additionally we are shipping HtrA Serine Peptidase 3 Antibodies (22) and HtrA Serine Peptidase 3 Kits (16) and many more products for this protein.
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Human HTRA3 Protein expressed in Insect Cells - ABIN807971
Dynon, Heng, Puryer, Li, Walton, Endo, Nie: HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening. in PLoS ONE 2012
HTRA3 may be involved in folliculogenesis and luteinisation in the primate ovary. HTRA3 is possibly a factor involved in and potentially important for primate placentation.
New insights into the structure and function of DeltaN-HtrA3 (show CAPN5 Proteins), which seems to have a unique combination of features among human HtrA (show HTRA1 Proteins) proteases.
HtrA3 (show CAPN5 Proteins) is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cance
HtrA1 (show HTRA1 Proteins) and HtrA3 (show CAPN5 Proteins) are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion.
Data indicate that the levels of high temperature requirement factor A3 (HtrA3)protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 (show CAPN5 Proteins) were in epithelial ovarian cancer.
Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 (show CAPN5 Proteins) was lower in patients with estrogen receptor (ER (show ESR1 Proteins))- and progesterone receptor (PR (show PGR Proteins))-positive tumors.
HtrA3 (show CAPN5 Proteins) may have a role as an early marker for preeclampsia
results suggest that HtrA3 (show CAPN5 Proteins) variants may play different roles in cancer development, and that the increased HtrA3 (show CAPN5 Proteins)-L levels in thyroid tissue could be correlated with the development of malignant lesions
HTRA3 (show CAPN5 Proteins) is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
decidual HtrA3 (show CAPN5 Proteins) negatively regulates trophoblast invasion
Abnormally high levels of serum HtrA3 (show CAPN5 Proteins) at approximately 13-14 wk of gestation is associated with preeclampsia
Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).
Trypsin-like serine protease
, HtrA serine peptidase 3
, probable serine protease HTRA3-like
, high-temperature requirement factor A3
, pregnancy-related serine protease
, probable serine protease HTRA3
, serine protease HTRA3
, toll-associated serine protease