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Hyaluronan and Proteoglycan Link Protein 1 Proteins (HAPLN1)

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.. Additionally we are shipping HAPLN1 Antibodies (50) and HAPLN1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAPLN1 1404 P10915
HAPLN1 12950 Q9QUP5
HAPLN1 29331  
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Top HAPLN1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,918.67
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$2,918.67
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,937.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,937.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,938.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$510.36
Details

HAPLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced HAPLN1 Proteins

  1. Human HAPLN1 Protein expressed in Human Cells - ABIN2002566 : Sun, Kobayashi, Suzuki, Kanayama, Terao: Production of cartilage link protein by human granulosa-lutein cells. in The Journal of endocrinology 2002 (PubMed)
    Show all 3 references for ABIN2002566

  2. Human HAPLN1 Protein expressed in Wheat germ - ABIN1306351 : Mathur, Blais, Goparaju, Neubert, Pass, Levon: Development of a biosensor for detection of pleural mesothelioma cancer biomarker using surface imprinting. in PLoS ONE 2013 (PubMed)

More Proteins for Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) Interaction Partners

Zebrafish Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. Hapln1a-ECM (show MMRN1 Proteins) stabilizes the secreted growth factor (show WNT2 Proteins) Semaphorin3d (Sema3d (show SEMA3D Proteins)), which has been independently shown to mediate Cx43 (show GJA1 Proteins) dependent phenotypes during regeneration.

  2. Hapln1a has a critical role in connexin43 (show GJA1 Proteins)-dependent growth and patterning in the regenerating fin skeleton

  3. The cloning and characterization of crtl1 and its expression during embryogenesis are reported.

Cow (Bovine) Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. stimulates proteoglycan (show Vcan Proteins) and types II and IX collagens in intervertebral disc cells - stimulates synthesis of matrix molecules

Human Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. CSGalNAcT-1 (show CSGALNACT1 Proteins) and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis.

  2. HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells

  3. Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.

  4. An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation.

  5. link protein may function as a stabilizer of the interaction between aggrecan (show ACAN Proteins) and hyaluronan in cartilage and between versican (show Vcan Proteins) and hyaluronan in many tissues

  6. SOX9 (show SOX9 Proteins) is a key regulator of CRTL1

  7. cLP (show CALML3 Proteins) and versican (show Vcan Proteins) did not bind directly to each other in solution yet formed ternary complexes with hyaluronan

  8. Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment.

Mouse (Murine) Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. Aggrecan (show ACAN Proteins), link protein and TN-R (show TNR Proteins) were identified to be essential for the neuroprotective properties of the perineuronal net.

  2. Mef2c (show MEF2C Proteins) regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.

  3. our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS

  4. there is a general and systemic function of link protein in the organization of extracellular matrix in a number of tissues, possibly interacting with other proteoglycans, such as versican (show Vcan Proteins), brevican (show BCAN Proteins), and neurocan (show NCAN Proteins)

  5. Data suggest that the reported temporal co-expression of cartilage link protein and neurocan (show NCAN Proteins) in developing brain implicates the possibility of a cooperative function of these molecules.

  6. reduced versican (show Vcan Proteins) expression may contribute to a subset of the cardiac abnormalities observed in the Crtl1(-/-) mouse.

HAPLN1 Protein Profile

Protein Summary

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Gene names and symbols associated with HAPLN1

  • hyaluronan and proteoglycan link protein 1 (HAPLN1)
  • hyaluronan and proteoglycan link protein 1a (hapln1a)
  • hyaluronan and proteoglycan link protein 1 (Hapln1)
  • BB099155 protein
  • CLP protein
  • Crtl1 protein
  • Crtl1l protein
  • CTRL1 protein
  • hapln1 protein
  • LP protein
  • LP-1 protein
  • wu:fc26f11 protein
  • wu:fc37g04 protein
  • wu:fc50e12 protein
  • wu:fc55h01 protein

Protein level used designations for HAPLN1

hyaluronan and proteoglycan link protein 1 , cartilage linking protein 1 , fc26f11 , fc37g04 , fc50e12 , fc55h01 , hyaluronan proteoglycan link protein 1 , cartilage link protein , cartilage-link protein , cartilage-linking protein 1 , proteoglycan link protein , Cartilage link protein , cartilage link protein 1 , link protein , LP , link protein precursor (AA -15 to 339)

GENE ID SPECIES
461765 Pan troglodytes
488921 Canis lupus familiaris
493635 Danio rerio
712501 Macaca mulatta
100442758 Pongo abelii
100605865 Nomascus leucogenys
281717 Bos taurus
1404 Homo sapiens
12950 Mus musculus
29331 Rattus norvegicus
396475 Gallus gallus
100034208 Equus caballus
445513 Sus scrofa
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