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HPGD encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. Additionally we are shipping HPGD Antibodies (127) and HPGD Kits (17) and many more products for this protein.
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Human HPGD Protein expressed in Wheat germ - ABIN1307031
Hughes, Otani, Yang, Newman, Yantiss, Altorki, Port, Yan, Markowitz, Mazumdar, Tai, Subbaramaiah, Dannenberg: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2009
15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.
the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.
15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC (show FAM126A Proteins)) and in human HCC (show FAM126A Proteins) biopsies.
Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.
prostaglandin E synthase (show PTGES Proteins) (cPGES/p23 (show PTGES3 Proteins)) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).
I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk (show GCK Proteins)-rs1 (show RS1 Proteins)) and downregulation of hydroxyprostaglandin dehydrogenase.
OAT (show OAT Proteins)-PG is proposed to be involved in the local PGE (show LIPF Proteins)(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.
novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression
15-Hydroxyprostaglandin dehydrogenase (show CBR1 Proteins) has a role in suppressing colon tumorigenesis
The intrarenal distribution of 15-PGDH and its interactions with COX-2 suggest that differential regulation of COX-2 and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis.
Data indicate that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor TD88 could be a good effector on wound healing, especially in the aspects of prevention of scarring.
The data indicate that decreased expression of 15-hydroxyprostaglandin dehydrogenase in the fetal membranes may contribute to the increase in intrauterine prostaglandin concentrations at term, stimulating the onset of labor.
miR (show MLXIP Proteins)-21-HPGD regulatory module may play an important role as part of a feed-forward loop that regulates the PGE2 signaling. Such a feed-forward regulatory mechanism likely plays a critical role in OTSCC initiation and progression.
inhibitory effects of 17-AAG (show MPG Proteins) on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression.
A common mutation and a novel mutation in HPGD gene were identified to be responsible for primary hypertrophic osteoarthropathy
Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.
Neoadjuvant chemotherapy could increase 15-PGDH expression in advanced gastric cancer patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to therapy.
15-PGDH mRNA levels were significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors.
Omega-3 polyunsaturated fatty acids upregulate the expression of 15-PGDH by inhibiting miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-26b.
Multiple drug resistance-associated protein (show ABCC1 Proteins) 4 (MRP4 (show ABCC4 Proteins)), prostaglandin transporter (PGT (show SLCO2A1 Proteins)), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.
Loss of PGDH expression is associated with esophageal squamous cell carcinoma and adenocarcinoma.
A single nucleotide polymorphism in the 3' untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene modifies mir (show MLXIP Proteins)-485-5p binding in breast cancer.
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
, hydroxyprostaglandin dehydrogenase 15-(NAD)
, 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
, prostaglandin dehydrogenase 1
, NAD-dependent 15-hydroxyprostaglandin dehydrogenase
, 15-hydroxyprostaglandin dehydrogenase (NAD+)
, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
, short chain dehydrogenase/reductase family 36C, member 1
, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase