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Hydroxysteroid (17-Beta) Dehydrogenase 3 Proteins (HSD17B3)

This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. Additionally we are shipping HSD17B3 Antibodies (49) and HSD17B3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSD17B3 15487 P70385
HSD17B3 117182 O54939
HSD17B3 3293 P37058
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Top HSD17B3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HSD17B3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3) Interaction Partners

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3) interaction partners

  1. High 4-tert (show TERT Proteins)-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD (show HAL Proteins) and AR expression.

  2. Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (show CYP11A1 Proteins), P450 (show POR Proteins)(17alpha) and 17beta-HSD (show HSD17B1 Proteins) in mice.

Human Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3) interaction partners

  1. Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH (show NQO1 Proteins).

  2. Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.

  3. Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.

  4. Expression of the genes HSD3B1 (show HSD3B1 Proteins), HSD17B3, and SRD5A2 (show SRD5A2 Proteins) was significantly increased in BPH (show GLI3 Proteins) tissues compared to normal adjacent prostate tissues.

  5. Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty

  6. 38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency.

  7. These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.

  8. 68 males with testicular 17beta-HSD deficiency were identified among a highly inbred Arab population in Israel as affected with male pseudohermaphroditism. [Review]

  9. The H8 haplotype of the HSD17B3 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.

  10. Case Report: rare form of 46,XY disorders of sexual development, associated to a novel gene nonsense mutation of HSD17B3 gene.

HSD17B3 Protein Profile

Protein Summary

This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.

Gene names and symbols associated with HSD17B3

  • hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3)
  • hydroxysteroid (17-beta) dehydrogenase 3 (HSD17B3)
  • EDH17B3 protein
  • SDR12C2 protein

Protein level used designations for HSD17B3

17(beta)HSD type 3 , 17-beta-HSD 3 , 17-beta-hydroxysteroid dehydrogenase type 3 , testicular 17-beta-hydroxysteroid dehydrogenase , testosterone 17-beta-dehydrogenase 3 , 17beta-HSD , estradiol 17 beta-dehydrogenase 3 , 17-beta-HSD3 , short chain dehydrogenase/reductase family 12C, member 2

GENE ID SPECIES
15487 Mus musculus
117182 Rattus norvegicus
3293 Homo sapiens
100513224 Sus scrofa
616934 Bos taurus
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