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The protein encoded by HCRTR1 is a G-protein coupled receptor involved in the regulation of feeding behavior. Additionally we are shipping Hypocretin (Orexin) Receptor 1 Antibodies (81) and Hypocretin (Orexin) Receptor 1 Kits (8) and many more products for this protein.
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Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR1 gene.
This study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution.
the orexinA/OX1 (show NQO1 Proteins) receptor axis has a significant pro-survival function in adrenal cells.
OX1R signaling can attenuate KOR (show OPRK1 Proteins)-mediated reduction of cellular cAMP levels while enhancing KOR (show OPRK1 Proteins)-mediated beta-arrestin recruitment and p38 (show CRK Proteins) activation.
OX1R and KOR (show OPRK1 Proteins) heterodimerize, and this heterodimer associates with Galphas (show GNAS Proteins), leading to increased protein kinase A (PKA) signaling pathway activity, including upregulation of intracellular cAMP levels.
Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data.
Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC (show SGCB Proteins)-7901 gastric cancer cells through the ERK (show EPHB2 Proteins) signaling pathway.
Orexin receptor binding was strongly dependent on the extracellular Ca(2 (show CA2 Proteins)+) concentration.
No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRTR1 polymorphisms.
Study provides pharmacological and molecular evidence indicating, respectively, a role for OXR1 (show OXR1 Proteins) signaling in ethanol and saccharin binge-like drinking
orexin activation of OX1R in the bone locally suppresses bone formation and enhances bone resorption by lowering osseous ghrelin (show GHRL Proteins) expression.
findings demonstrate that Hcrtr-1 modulates the reinforcing properties of cannabinoids.
The transcripts for the Orx1 and Orx2 receptors diverged in the basolateral amygdala with Orx1 increasing and Orx2 decreasing in animals that were susceptible to the chronic defeat.
more severe depressive behavior was associated with reduced hippocampal orexin expression, contrasted with increased orexin plus Orx1 receptor mRNA expression in the amygdala.
data demonstrate that hypocretin signaling acting on Hcrtr-1 in the PVN plays a crucial role in the expression of nicotine withdrawal.
Dynlt1 (show DYNLT1 Proteins) modulates orexin signaling by regulating OX1R
results indicate that hcrtr1 and 2 signaling oppose one another in the regulation of depression-like behaviors.
These results suggest that orexin and its receptor may play roles in traumatic brain injury, and that OX1R is induced in neurons and microglial cells after traumatic brain injury.
These data suggest that activation of the Ox1r is a necessary component of food-reinforced responding, motivation, or both in normal mice
These data confirmed expression of orexin and its two receptors in the bovine adrenal gland.
first evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract
39 of 41 in: Acta Histochem. 2014 Jan;116(1) Orexin 1 receptor is expressed in the seminiferous tubules of boar testis.
Immunoreactivity (IR) for both orexins A and B (OXA and OXB), and cognate receptors (OX1R and OX2R (show HCRTR2 Proteins)) were identified only in the excretory striated (show NSDHL Proteins) ducts of the MSG while acinar cells were not immunoreactive.
Data demonstrated the presence of OX1R and OX2R (show HCRTR2 Proteins) genes and proteins in the ovary of the pig and the impact of the hormonal milieu on the expression of both receptors.
expression of OX1R and Ox2R (show HCRTR2 Proteins) in hypothalamus during oestrous cycle; evidence OX1R and OX2R (show HCRTR2 Proteins) mRNAs and proteins occur in hypothalamic structures engaged in control of reproduction; indicate dependence of OXR expression on endocrine reproductive state
findings provide the first evidence that orexin receptors 1 and 2 messenger RNAs and proteins occur in the pituitary of the pig and indicate the dependence of orexin receptor expression on the endocrine reproductive state
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
orexin receptor 1
, hypocretin (orexin) receptor 1
, orexin receptor type 1-like
, hypocretin receptor 1
, hypocretin receptor type 1
, hypocretin receptor-1
, orexin receptor type 1
, orexin receptor-1