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The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Proteins (29) and ISG15 Kits (21) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal ISG15 Primary Antibody for EIA, WB - ABIN116955
Potter, Narasimhan, Mende-Mueller, Haas: Precursor processing of pro-ISG15/UCRP, an interferon-beta-induced ubiquitin-like protein. in The Journal of biological chemistry 1999
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Human Polyclonal ISG15 Primary Antibody for EIA, IHC (p) - ABIN356680
Padovan, Terracciano, Certa, Jacobs, Reschner, Bolli, Spagnoli, Borden, Heberer: Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells. in Cancer research 2002
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Human Polyclonal ISG15 Primary Antibody for IHC (p), WB - ABIN387983
Meraro, Gleit-Kielmanowicz, Hauser, Levi et al.: IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding ... in Journal of immunology (Baltimore, Md. : 1950) 2002
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Human Polyclonal ISG15 Primary Antibody for EIA, IHC (p) - ABIN356679
Reich, Evans, Levy, Fahey, Knight, Darnell: Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. in Proceedings of the National Academy of Sciences of the United States of America 1987
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Human Polyclonal ISG15 Primary Antibody for EIA, WB - ABIN4620431
Blomstrom, Fahey, Kutny, Korant, Knight: Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence. in The Journal of biological chemistry 1986
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Human Polyclonal ISG15 Primary Antibody for IHC, IHC (p) - ABIN4327696
Harris, Tabb, Sodora, Paiardini, Klatt, Douek, Silvestri, Müller-Trutwin, Vasile-Pandrea, Apetrei, Hirsch, Lifson, Brenchley, Estes: Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. in Journal of virology 2010
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Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.
NSP2 (show RTN2 Antibodies) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.
Results report identification and cloning of the ISG15 and ISG43 (show USP18 Antibodies) genes in pig.
The results suggest that integrin-adhesion-induced MRTF-A (show MKL1 Antibodies)-SRF activation and ISG15 expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.
These data indicate that hepatic expression of PSMA6 (show PSMA6 Antibodies), which is upregulated during viral hepatitis, likely depends on TLR3 (show TLR3 Antibodies) activation and, that PSMA6 (show PSMA6 Antibodies) affects the expression of immunoregulatory ISG15, a proviral factor in the pathogenesis of hepatitis C virus infection.
ISG15 dysregulation may be involved in the pathogenesis of glomerular inflammation
This study shows that interferon (show IFNA Antibodies)-stimulated gene 15 (ISG15) lowers Human respiratory syncytial virus growth through protein ISGylation.
Data show the induction of signal transducer and activator of transcription (STAT)1 (show STAT1 Antibodies) and IFN-stimulated gene 15 protein (ISG15) in Rickettsia conorii-infected human umbilical vein endothelial cells (HUVECs).
ISG15 is elevated in viremic HIV-1 patients and is associated with high TRAIL and IDO (show IDO1 Antibodies) levels.
ISG15 might serve as a novel prognostic biomarker in drinkers with esophageal squamous cell cancer
Cellular ubiquitin is a substrate of ISG15 and Lys (show LYZ Antibodies) 29 on ubiquitin is the major ISG15 acceptor site.
Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon (show IFNA Antibodies) inducible protein ISG15.
The inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to substrates by HERC5 (show HERC5 Antibodies).
Posttranslational protein modification by ISG15 plays an important role in antiviral defense
These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK (show MYLK Antibodies) elevation, development of BBB (show ALMS1 Antibodies) disruption, and cerebral edema.
Kruppel-like factor 9 (KLF9 (show KLF9 Antibodies)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.
Propose that Isg15-dependent degradation of p53 (show TP53 Antibodies) represents an alternative mechanism of controlling p53 (show TP53 Antibodies) protein levels, and, thus, it is an attractive pathway for drug discovery.
Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.
Enhanced resistance upon influenza B infection in USP18 (show USP18 Antibodies)(C61A/C61A (show BRCC3 Antibodies)) mice was completely reversed in USP18 (show USP18 Antibodies)(C61A/C61A (show BRCC3 Antibodies)) mice, which additionally lack ISG15, providing evidence that the observed reduction in viral titers is ISG15 dependent
Authors found that ISG15 protects mice from influenza A virus and Sendai virus induced lethality by a conjugation-dependent mechanism in both of these models.
study demonstrated that ISG15 had an anti-apoptotic effect on the beta cell line MIN6; conclusion is consistent with previous reports that ISG15 has a protective role
The ISG15 conjugation system represents a critical innate response mechanism in cardiomyocytes to fight the battle against invading pathogens, limiting inflammatory cardiomyopathy, heart failure, and death.
ISG15 does not appear to play a key role in IFN-beta (show IFNB1 Antibodies)-mediated C2C12 myoblast cell fusion
Data indicate that the expression profiles of ISG15, MX1 (show MX1 Antibodies), MX2 (show MX2 Antibodies), and OAS1 (show OAS1 Antibodies) could be a useful diagnostic biomarker of gestation.
ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.
ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy
interferon-stimulated protein (show ISG20 Antibodies)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells
rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
ISG15 ubiquitin-like modifier
, interferon stimulated gene, 15 kDa
, interferon, alpha-inducible protein
, ubiquitin-like protein ISG15
, interferon-induced 17 kDa protein
, interferon, alpha-inducible protein (clone IFI-15K)
, interferon-induced 17-kDa/15-kDa protein
, interferon-stimulated protein, 15 kDa
, ubiquitin cross-reactive protein
, interferon-stimulated protein 15
, interferon-induced 15 kDa protein
, interferon-induced 15-KDa protein
, interferon-stimulated protein (15 kDa)
, interferon-stimulated gene product 17