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IER3 functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Additionally we are shipping IER3 Proteins (6) and IER3 Kits (4) and many more products for this protein.
Showing 10 out of 47 products:
Human Polyclonal IER3 Primary Antibody for IHC, ELISA - ABIN1002470
Kondratyev, Chung, Jung: Identification and characterization of a radiation-inducible glycosylated human early-response gene. in Cancer research 1996
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Human Polyclonal IER3 Primary Antibody for EIA, IHC (p) - ABIN499960
Wu, Ao, Prasad, Wu, Schlossman: IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. in Science (New York, N.Y.) 1998
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Human Polyclonal IER3 Primary Antibody for FACS, IF - ABIN655735
Fellay, Ge, Shianna, Colombo, Ledergerber, Cirulli, Urban, Zhang, Gumbs, Smith, Castagna, Cozzi-Lepri, De Luca, Easterbrook, Günthard, Mallal, Mussini, Dalmau, Martinez-Picado, Miro, Obel, Wolinsky, Martinson, Detels, Margolick, Jacobson, Descombes, Anton: Common genetic variation and the control of HIV-1 in humans. in PLoS genetics 2009
Show all 3 references for ABIN655735
Human Polyclonal IER3 Primary Antibody for EIA, FACS - ABIN952818
Ouakaa-Kchaou, Elloumi, Kochlef, Gargouri, Kharrat, Kilani, Ghorbel: Ovarian Crohn's disease. in Journal of Crohn's & colitis 2010
Show all 2 references for ABIN952818
interleukin-1beta (IL-1beta (show IL1B Antibodies))-induced IER3 expression is mediated by the ERK1/2 (show MAPK1/3 Antibodies) target, transcription factor Elk-1 (show ELK1 Antibodies).
findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
High expression of IER3 is associated with hepatocarcinoma.
In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
IEX-1 expression levels correlate with the severity of preeclampsia
Studied the binding effect of hcmv-miR (show MLXIP Antibodies)-UL148D to the 3' untranslated region (3'UTR (show UTS2R Antibodies)) of IEX-1.Results showed that only one binding site in the 3'UTR (show UTS2R Antibodies) of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir (show MLXIP Antibodies)-UL148D.
the interference of IER3 with the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)-Fyn (show FYN Antibodies) pathway represents a novel mechanism of Nrf2 (show GABPA Antibodies) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IEX-1 plays a role in suppression of apoptosis and protects cells by controlling sensitivity to TNFalpha (show TNF Antibodies) under both normal and inflammatory conditions.
Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.
Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.
these results indicate that IER3 is a key player in expanding the pool of APC (show APC Antibodies) while highlighting the role of distinct effectors found in an obese microenvironment in this process
Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A (show VEGFA Antibodies)/Mcp-1 (show CPT1B Antibodies) axis and Mmp-9 (show MMP9 Antibodies).
IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 (show MAPK1/3 Antibodies) phosphorylation via phosphatase PP2A (show PPP2R2B Antibodies) inhibition.
Stress-induced hematopoietic failure in the absence of immediate early (show JUN Antibodies) response gene X-1 (IEX-1, IER3).
the interference of IER3 with the PI3K/Akt (show AKT1 Antibodies)-Fyn (show FYN Antibodies) pathway represents a novel mechanism of Nrf2 (show NFE2L2 Antibodies) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IEX-1 has a role in activation of Erk (show EPHB2 Antibodies) and NF-kB pathways, which affects thrombopoietin (show THPO Antibodies)-promoted NHEJ DNA repair in hematopoietic stem cells
Data suggest a role for the immediate early (show JUN Antibodies) response gene X-1 (IEX-1) in the control of colon epithelial homeostasis.
Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 (show HAND1 Antibodies) cells
IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways
Mcl-1 (show MCL1 Antibodies) translocation to the nucleus is a general response to genotoxic stress that is strictly and timely controlled by IEX-1 in response to DNA damage. Loss of IEX-1 leads to genomic instability.
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.
immediate early response 3
, radiation-inducible immediate-early gene IEX-1
, ATP-binding cassette, sub-family F (GCN20), member 1
, PACAP-responsive gene 1 protein
, anti-death protein
, differentiation-dependent gene 2 protein
, expressed in pancreatic carcinoma
, gly96, mouse, homolog of
, immediate early protein GLY96
, immediate early response 3 protein
, immediately early gene X-1
, protein DIF-2
, cAMP inducible gene 3