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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Additionally we are shipping Inhibitor of Growth Family, Member 4 Proteins (8) and Inhibitor of Growth Family, Member 4 Kits (1) and many more products for this protein.
Showing 10 out of 54 products:
Human Polyclonal ING4 Primary Antibody for WB - ABIN1944775
Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. in Cancer research 2003
Show all 4 Pubmed References
Human Polyclonal ING4 Primary Antibody for ELISA, WB - ABIN105223
Unoki, Shen, Zheng, Harris: Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas.
ING4 directly binds the Miz1 (show ZBTB17 Antibodies) promoter and is required to induce Miz1 (show ZBTB17 Antibodies) mRNA and protein expression during luminal cell differentiation.
The oncogenic role of miR (show MLXIP Antibodies)-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4.
ING4 binds double-stranded DNA through its central region with micromolar affinity.
results indicate that the combination of ING4 and PTEN (show PTEN Antibodies) may provide an effective therapeutic strategy for HCC (show FAM126A Antibodies)
ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed
ING4 inhibits CRC (show CALR Antibodies) invasion and metastasis probably via a switch from mesenchymal marker N-cadherin (show CDH2 Antibodies) to epithelial marker E-cadherin (show CDH1 Antibodies) through downregulation of Snail1 (show SNAI1 Antibodies) epithelial-mesenchymal transition (EMT (show ITK Antibodies))-inducing transcription factor (EMT (show ITK Antibodies)-TF).
Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG (show TDG Antibodies))-Fas (show FAS Antibodies) protein axis to promote apoptosis resistance in pancreatic cancer.
MiR (show MLXIP Antibodies)-761 directly targeted ING4 and TIMP2 (show TIMP2 Antibodies).
Data suggest a close connection between aberrant ING4 expression and the carcinogenesis of human bladder cells.
ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (show FAS Antibodies)-induced apoptosis in a caspase-8 (show CASP8 Antibodies)-dependent pathway.
Inhibitor of growth (show ING1 Antibodies)-4 promotes IkappaB promoter activation to suppress NF-kappaB (show NFKB1 Antibodies) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein