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Inositol(myo)-1(or 4)-Monophosphatase 1 Proteins (IMPA1)

IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. Additionally we are shipping Inositol(myo)-1(or 4)-Monophosphatase 1 Antibodies (23) and Inositol(myo)-1(or 4)-Monophosphatase 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IMPA1 55980  
IMPA1 83523 P97697
IMPA1 3612 P29218
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Top Inositol(myo)-1(or 4)-Monophosphatase 1 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mesembryanthemum crystallinum His tag   1 mg Log in to see 56 to 66 Days
$2,704.17
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,724.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,724.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,724.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,724.33
Details

IMPA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

Top referenced Inositol(myo)-1(or 4)-Monophosphatase 1 Proteins

  1. Human IMPA1 Protein expressed in Escherichia coli (E. coli) - ABIN667229 : Bone, Springer, Atack: Structure of inositol monophosphatase, the putative target of lithium therapy. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 2 references for ABIN667229

More Proteins for Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Interaction Partners

Mouse (Murine) Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function

  2. local synthesis of IMPA1 is required for neurotrophin (show BDNF Proteins)-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases

  3. IMPA1 was expressed in round spermatids

  4. Results suggest that calbindin D28k (show CALB1 Proteins) acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.

  5. IMPA2 (show IMPA2 Proteins) has a separate function in vivo from that of IMPA1

  6. IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium

Human Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 (show IMPA2 Proteins) transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.

  2. IMPA2 (show IMPA2 Proteins) has a separate function in vivo from that of IMPA1

Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) Protein Profile

Protein Summary

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Gene names and symbols associated with IMPA1

  • inositol(myo)-1(or 4)-monophosphatase 1 (impa1)
  • inositol (myo)-1(or 4)-monophosphatase 1 (Impa1)
  • Inositol (myo)-1(or 4)-monophosphatase 1 (Impa1)
  • inositol monophosphatase (impa1)
  • inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1)
  • 2610002K09Rik protein
  • 2900059K10Rik protein
  • AI325909 protein
  • IMP protein
  • impa protein
  • zgc:100926 protein

Protein level used designations for IMPA1

inositol monophosphatase 1 , Inositol monophosphatase , IMP 1 , IMPase 1 , inositol-1(or 4)-monophosphatase 1 , lithium-sensitive myo-inositol monophosphatase A1 , myo-inositol monophosphatase

GENE ID SPECIES
437018 Danio rerio
100301752 Oncorhynchus mykiss
100380569 Salmo salar
55980 Mus musculus
83523 Rattus norvegicus
397905 Xenopus laevis
3612 Homo sapiens
444552 Xenopus laevis
477925 Canis lupus familiaris
397425 Sus scrofa
281865 Bos taurus
100174641 Pongo abelii
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