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IMPAD1 encodes a member of the inositol monophosphatase family. Additionally we are shipping Inositol Monophosphatase Domain Containing 1 Proteins (8) and Inositol Monophosphatase Domain Containing 1 Kits (5) and many more products for this protein.
Showing 10 out of 32 products:
Human Monoclonal IMPAD1 Primary Antibody for WB - ABIN394221
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN394221
Human Polyclonal IMPAD1 Primary Antibody for WB - ABIN2782915
Zhang, Li, Martin, Aebersold: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. in Nature biotechnology 2003
In human B cells, SPPL2a (show SPPL2A Antibodies) is indispensable for turnover of CD74 (show CD74 Antibodies) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a (show SPPL2A Antibodies) transcript and protein.
Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a (show SPPL2A Antibodies)).
concluded that IMPAD1 should be screened for patients with Catel-Manzke and additional features
Data show that endogenous SPPL2a (show SPPL2A Antibodies) - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.
Affected individuals carried homozygous missense mutations in IMPAD1, the gene coding for gPAPP, a Golgi-resident nucleotide phosphatase that hydrolyzes phosphoadenosine phosphate (PAP (show REG3A Antibodies)), the byproduct of sulfotransferase reactions, to AMP (show APRT Antibodies).
SPP (show SPEB Antibodies), SPPL2a (show SPPL2A Antibodies), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis
ADAM10 (show ADAM10 Antibodies) and SPPL2a (show SPPL2A Antibodies) were identified as two proteases implicated in FasL (show FASL Antibodies) processing and release of the FasL (show FASL Antibodies) intracellular domain, which has been shown to be important for retrograde FasL (show FASL Antibodies) signaling
SPPL2a (show SPPL2A Antibodies) and SPPL2b (show SPPL2B Antibodies) mediate the intramembrane cleavage, whereas neither SPP (show SPEB Antibodies) nor SPPL3 (show SPPL3 Antibodies) is capable of processing the Bri2 (show ITM2B Antibodies) N-terminal fragment.
Golgi plays an important role in glycosaminoglycan sulfation and define a function for gPAPP in the formation of skeletal elements derived through endochondral ossification[3'-phosphoadenosine 5'-phosphate phosphatase]
identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations in the embryonic skeleton
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.
inositol monophosphatase domain containing 1
, myo-inositol monophosphatase A3
, inositol monophosphatase 3
, inositol monophosphatase 3-like
, Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
, IMPase 3
, golgi-resident PAP phosphatase
, inositol monophosphatase domain-containing protein 1
, inositol-1(or 4)-monophosphatase 3
, Golgi-resident PAP phosphatase
, IMP 3
, Inositol monophosphatase domain-containing protein 1
, Inositol-1(or 4)-monophosphatase 3
, Myo-inositol monophosphatase A3
, SPP-like 2A
, intramembrane cleaving protease
, intramembrane protease 3
, presenilin-like protein 2
, signal peptide peptidase-like 2A