Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) Proteins (ITGAE)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Additionally we are shipping ITGAE Antibodies (345) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITGAE 16407 Q60677
Rat ITGAE ITGAE 83577  
ITGAE 3682 P38570
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Top ITGAE Proteins at antibodies-online.com

Showing 6 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$907.50
Details

ITGAE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaction Partners

Mouse (Murine) Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) interaction partners

  1. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  2. Mesenteric lymph node CD11b (show ITGAM Proteins)(-) CD103(+) PD-L1 (show CD274 Proteins)(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (show TGFB1 Proteins) activation.

  3. NR4A3 (show NR4A3 Proteins) plays an important role in the regulation of CD103+ mDCs by regulating CCR7 (show CCR7 Proteins)-dependent cell migration.

  4. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4 (show TIMD4 Proteins)) on a proportion of CD103+ CD11b (show ITGAM Proteins)+ dendritic cell (DC) in the intestinal lamina propria (LP).

  5. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice

  6. Intestinal CD103(+)CD11b (show ITGAM Proteins)(-) dendritic cells restrain colitis via IFN-gamma-induced (show SAMHD1 Proteins) anti-inflammatory response in epithelial cells.

  7. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b (show ITGAM Proteins)+ dendritic cells to suppress allergic inflammation.

  8. CD103 on FoxP3 (show FOXP3 Proteins)+ Treg cells was involved in Treg retention to inflamed skin.

  9. Interleukin-12-producing CD103+ CD11b (show ITGAM Proteins)- CD8 (show CD8A Proteins)+ dendritic cells are responsible for eliciting gut (show GUSB Proteins) intraepithelial lymphocyte response against Encephalitozoon cuniculi.

  10. An important role for CD103 in the control of airway inflammation in asthma.

Human Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) interaction partners

  1. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  2. The CD103+CD4+/CD4 (show CD4 Proteins)+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4 (show CD4 Proteins)+/CD8 (show CD8A Proteins)+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis.

  3. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll (show TLR4 Proteins)-like receptor ligands.

  4. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma

  5. Levels of GZMA (show GZMA Proteins) and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.

  6. PD-1 (show PDCD1 Proteins)(+)CD103(+) CD8 (show CD8A Proteins) TIL (show TLR1 Proteins) might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation.

  7. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease.

  8. Cell-sorting experiments demonstrated that IDO1 (show IDO1 Proteins) expression is found in a subset of CD1a (show CD1A Proteins)(+)CD14 (show NDUFA2 Proteins)(-)langerin (show CD207 Proteins)(+) cells, expressing CD103

  9. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas.

  10. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.

ITGAE Protein Profile

Protein Summary

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

Gene names and symbols associated with ITGAE

  • integrin alpha E, epithelial-associated (Itgae)
  • integrin, alpha E (Itgae)
  • integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) (ITGAE)
  • A530055J10 protein
  • alpha-E1 protein
  • alpha-M290 protein
  • aM290 protein
  • CD103 protein
  • HUMINAE protein

Protein level used designations for ITGAE

integrin alpha M290 , integrin alpha-E , integrin alpha E1, epithelial-associated , integrin, alpha E, epithelial-associated , HML-1 antigen , antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide , integrin alpha-IEL , mucosal lymphocyte 1 antigen

GENE ID SPECIES
16407 Mus musculus
83577 Rattus norvegicus
3682 Homo sapiens
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