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Integrin beta 4 Proteins (ITGB4)

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Additionally we are shipping Integrin beta 4 Antibodies (372) and Integrin beta 4 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITGB4 192897  
ITGB4 3691 P16144
Rat ITGB4 ITGB4 25724 Q64632
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Top Integrin beta 4 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$804.38
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ITGB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Integrin beta 4 (ITGB4) Interaction Partners

Mouse (Murine) Integrin beta 4 (ITGB4) interaction partners

  1. Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl (show ABL1 Proteins) transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl (show ABL1 Proteins) kinases and p73 (show ARHGAP24 Proteins) protein pathway(s).

  2. Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling.

  3. keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis

  4. Up-regulation of integrin beta4 and TRPV1 (show TRPV1 Proteins) in migrating keratinocytes.

  5. Ectopic induction of Nur77 (show NR4A1 Proteins) in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 (show NR4A1 Proteins) regulates the expression of integrin beta4 by targeting its promoter activity.

  6. Col17a1 (show COL17A1 Proteins)/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.

  7. Both annexin A7 (show ANXA7 Proteins) and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.

  8. Findings indicate a function for Id2 in regulating Snai1 (show SNAI1 Proteins)-mediated repression of integrin beta4.

  9. Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 (show TP53 Proteins) and Rb function in a model of prostate cancer (PB-TAg mice).

  10. Deficiency of integrin alpha(6 (show ITGA6 Proteins))beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.

Human Integrin beta 4 (ITGB4) interaction partners

  1. For the in vivo experiment, miR (show MLXIP Proteins)-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR (show MLXIP Proteins)-182-5p may be a key androgen receptor (show AR Proteins)-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.

  2. data indicate that the beta4 integrin/FAK (show PTK2 Proteins) complex and subsequent FAK (show PTK2 Proteins) activation are essential regulators during the tumorigenicity of colon cancer

  3. This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.

  4. analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]

  5. ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (show FAM126A Proteins) by conferring anchorage independence through EGFR (show EGFR Proteins)-dependent FAK (show PTK2 Proteins)-AKT (show AKT1 Proteins) activation.

  6. High vimentin and low beta4 integrin protein levels are associated with poor survival in oral squamous carcinoma patients.

  7. Endothelial cell overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression.

  8. This study describes a pro-metastatic EGFR (show EGFR Proteins)/Src (show SRC Proteins)-dependent beta4 integrin/FAK (show PTK2 Proteins) complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer.

  9. These data suggest that the p53 (show TP53 Proteins)(R248) mutant endows ovarian cancer cells with increased adhesiveness and that integrin beta4 and Akt (show AKT1 Proteins) signalling are associated with the mutation-enhanced ovarian cancer-mesothelial cell adhesion.

  10. Changes in beta-integrins gene expression in human prostate cancer cells following ITGB4 knockdown.

Cow (Bovine) Integrin beta 4 (ITGB4) interaction partners

Integrin beta 4 (ITGB4) Protein Profile

Protein Summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with Integrin beta 4 Proteins (ITGB4)

  • integrin, beta 4 (ITGB4)
  • integrin beta 4 (Itgb4)
  • integrin, beta 4 (Itgb4)
  • AA407042 protein
  • C230078O20 protein
  • CD104 protein

Protein level used designations for Integrin beta 4 Proteins (ITGB4)

integrin beta 4 , integrin beta-4 , CD104 antigen , GP150 , integrin beta-4 subunit

GENE ID SPECIES
100051679 Equus caballus
454887 Pan troglodytes
192897 Mus musculus
3691 Homo sapiens
25724 Rattus norvegicus
506995 Bos taurus
100718717 Cavia porcellus
483318 Canis lupus familiaris
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