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The protein encoded by IFI30 is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. Additionally we are shipping IFI30 Antibodies (43) and IFI30 Kits (8) and many more products for this protein.
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Human IFI30 Protein expressed in Escherichia coli (E. coli) - ABIN1098216
Arunachalam, Phan, Geuze, Cresswell: Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). in Proceedings of the National Academy of Sciences of the United States of America 2000
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GILT expression is up-regulated in spleen and kidney after immunization with LPS (show IRF6 Proteins) although it also is constitutively expressed in heart, liver, muscle and intestine, suggesting that GILT may be involved in the immune response to bacterial challenge.
GILT has a role in maintaining cysteine cathepsin proteolytic efficiency in phagosomes
These results show that wild-type mouse fibroblasts are relatively resistant and GILT(-/-)mouse fibroblasts are susceptible to Dengue virus 2 entry and replication.
Data indicate that in the absence of Gamma-interferon-inducible lysosomal thiol reductase (GIL (show AQP3 Proteins), CD4 (show CD4 Proteins)-positive T cell responses to major house dust mite allergen Der (show GDF3 Proteins) p 1 are significantly reduced.
GILT has a critical role in regulating CD4 (show CD4 Proteins)(+) T-cell tolerance to an endogenous skin-restricted antigen relevant to controlling autoimmunity and generating effective immunotherapy for melanoma.
We showed that STAT1 (show STAT1 Proteins) interacts with the GILT promoter, even in the absence of IFN-gamma (show IFNG Proteins), and that STAT1 (show STAT1 Proteins) represses GILT expression.
GILT has limited yet unexpected effect on self-peptide species presented by major histocompatibility complex class II antigens.
study shows GILT facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8 (show CD8A Proteins)+ T cells or cross-presentation;initiation of gB-specific CD8 (show CD8A Proteins)+ T cell response during HSV-1 infection or cross-priming is GILT-dependent
the thiol reductase activity of GILT is its essential function in MHC class II-restricted Ag processing
GILT appears to have a fundamental role in cellular proliferation mediated through its influence on SOD2 (show SOD2 Proteins) protein activity and expression.
findings show that endogenously produced peptide-IgG is processed by transduced splenic B cells in the lysosomes/endosomes in a GILT-dependent manner, and this endocytic processing pathway is essential for generating tolerogenic B cells
GILT expression is anticipated to result in improved presentation of melanoma antigens and more effective antimelanoma T-cell responses.
The lysosomal thiol reductase GILT expressed by antigen-presenting cells has diverse cellular and organismal functions. (Review)
this review discusses recent studies that have advanced our understanding of the role of GILT in antigen processing and revealed surprising new functions for the enzyme.[review]
Single nucleotide polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals.
GILT is required for efficient histocompatiblity class II-restricted processing of melanoma antigen tyrosinase-related protein 1 epitope in vitro and accelerates the onset of vitiligo in TRP1-specific T-cell receptor transgenic mice.
Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes.
Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT).
GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4 (show CD4 Proteins)+ T cell recognition
studied gene expression profile of brain lesions of a patient with Neuromyelitis optica by using DNA microarray; found marked up-regulation of interferon gamma-inducible protein 30 (IFI30), CD163 (show CD163 Proteins), and secreted phosphoprotein 1 (SPP1 (show SPP1 Proteins), osteopontin (show SPP1 Proteins))
The cloning and characterization of porcine gamma-interferon-inducible lysosomal thiol reductase (GILT) are reported.
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
, gamma-interferon-inducible lysosomal thiol reductase
, interferon, gamma-inducible protein 30
, interferon gamma inducible protein 30
, gamma-interferon-inducible protein IP-30
, lysosomal thio reductase IP30
, lysosomal thiol reductase IP30
, interferon gamma-inducible protein 30 preproprotein
, gamma-inducible protein 30
, gamma-interferon-inducible-lysosomal thiol reductase