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anti-Interferon Induced with Helicase C Domain 1 (IFIH1) Antibodies

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Additionally we are shipping Interferon Induced with Helicase C Domain 1 Kits (7) and Interferon Induced with Helicase C Domain 1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IFIH1 64135 Q9BYX4
IFIH1 71586 Q8R5F7
IFIH1 499801  
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Top anti-Interferon Induced with Helicase C Domain 1 Antibodies at antibodies-online.com

Showing 10 out of 127 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB IHC Information: Paraffin embedded spleen tissue, tested with an antib... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunohistochemistry of MDA5 in human lymph node tissue with this prod... Western blot analysis of MDA5 in Daudi cell lysate with AP30553PU-N MD... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence of MDA5 in Human Lymph Node cells with MDA5 Antibod... Immunohistochemistry of MDA5 in human lymph node tissue with MDA5 anti... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185002 (10µg/ml) staining of paraffin embedded Human Pancreas. Mic... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image MDA5 antibody [N2C1], Internal detects MDA5 protein at cyt... WB Image Sample (30 ug of whole cell lysate) A: Raji 7.5% SDS PAGE ant... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis anti-MDA5 (mouse), pAb (AL180)  detecting the cl... 100 μL Log in to see 5 to 8 Days
$404.25
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

IFIH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus)
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Top referenced anti-Interferon Induced with Helicase C Domain 1 Antibodies

  1. Human Polyclonal IFIH1 Primary Antibody for EIA, IF - ABIN500266 : Benesh, Liyanage: Surface-embedded Green-function method for general surfaces: Application to Al(111). in Physical review. B, Condensed matter 1999 (PubMed)
    Show all 6 references for ABIN500266

  2. Human Polyclonal IFIH1 Primary Antibody for EIA, IF - ABIN500264 : Hiscott, Nguyen, Arguello, Nakhaei, Paz: Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. in Oncogene 2006 (PubMed)
    Show all 5 references for ABIN500264

  3. Human Polyclonal IFIH1 Primary Antibody for IHC, ELISA - ABIN185002 : Kang, Gopalkrishnan, Wu, Jankowsky, Pyle, Fisher: mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 references for ABIN185002

  4. Human Polyclonal IFIH1 Primary Antibody for EIA, IHC (p) - ABIN374329 : Liao, Bao, Liu, Lai, Li, Garofalo, Casola: Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. in The Journal of general virology 2008 (PubMed)
    Show all 3 references for ABIN374329

  5. Mouse (Murine) Polyclonal IFIH1 Primary Antibody for IHC, WB - ABIN1169452 : Kovacsovics, Martinon, Micheau, Bodmer, Hofmann, Tschopp: Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. in Current biology : CB 2002 (PubMed)

  6. Mouse (Murine) Polyclonal IFIH1 Primary Antibody for ELISA, WB - ABIN190791 : Kato, Takeuchi, Sato, Yoneyama, Yamamoto, Matsui, Uematsu, Jung, Kawai, Ishii, Yamaguchi, Otsu, Tsujimura, Koh, Reis e Sousa, Matsuura, Fujita, Akira: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. in Nature 2006 (PubMed)

  7. Cow (Bovine) Polyclonal IFIH1 Primary Antibody for IHC, WB - ABIN2775253 : Qu, Marchand, Grabs, Polychronakos: The association between the IFIH1 locus and type 1 diabetes. in Diabetologia 2008 (PubMed)

More Antibodies against Interferon Induced with Helicase C Domain 1 Interaction Partners

Rhesus Monkey Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These findings indicate that human parainfluenza virus type 2 V binding to MDA5 is important for HPIV-2 virulence in nonhuman primates and that some V protein residues involved in MDA5 binding are not essential for efficient HPIV-2 growth in vitro.

Human Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These results showed that mRNA levels of MDA5 and RIG-1 (show RARRES3 Antibodies) were significantly decreased and increased, respectively, in chronic hepatitis B patients when compared to healthy controls.

  2. Findings indicate that melanoma differentiation associated protein-5 (MDA5) may serve as a complementary role in the toll (show TLR4 Antibodies)-like receptor3 (TLR3 (show TLR3 Antibodies)) activated suppression of neuroblastoma (show ARHGEF16 Antibodies) (NB).

  3. The MDA5 knockdown had no significant impact on the phosphorylation of eukaryotic translation initiation factor 2alpha (show EIF2S1 Antibodies) triggered by CCCP, and MDA5 itself was not recruited to SGs (show FBN1 Antibodies), and the regulation of MDA5 in the SG response occurs downstream of eIF2alpha (show EIF2A Antibodies).

  4. These results demonstrate that poliovirus infection actively suppresses the host type I interferon (show IFNA Antibodies) response by blocking activation of IRF-3 (show IRF3 Antibodies) and suggests that this is not mediated by cleavage of MDA-5 or IPS-1 (show MAVS Antibodies).

  5. Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Antibodies) suppresses the polyI:C-induced TLR3 (show TLR3 Antibodies) response mediated by TICAM1 (TRIF (show TICAM1 Antibodies)), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF (show MAVS Antibodies)).

  6. A significantly higher frequency of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was observed in Chinese patients with polymyositis/dermatomyositis (PM/DM) than in Japanese patients.

  7. MDA5 mediates neuroprotection against cerebral ischemic injury.

  8. discusses the different risk and protective IFIH1 alleles in the context of recent structural and functional analysis that relate to MDA5 regulation of interferon (show IFNA Antibodies) responses

  9. The study proposes that the turnover kinetics of the ATPase (show DNAH8 Antibodies) domain enables the discrimination of self/non-self RNA by both RIG-I (show DDX58 Antibodies) and MDA5.

  10. This review briefly summarizes the RLR (show DHX58 Antibodies) system, and focuses on the relationship between LGP2 (show DHX58 Antibodies) and MDA5, describing in detail how these two proteins work together to detect foreign RNA and generate a fully functional antiviral response.

Mouse (Murine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. The p150 (show ABL1 Antibodies) isoform of ADAR1 (show ADAR Antibodies) uniquely regulated the MDA5 pathway.

  2. MDA5, detects viral RNA and triggers induction of type I interferons, chemical messengers that induce inflammation and help regulate the immune responses.

  3. Duox2 (show DUOX1 Antibodies)-derived reactive oxygen species are necessary for the innate immune response and trigger the induction of RIG-I (show DDX58 Antibodies) and MDA5 to resist influenza A infection in human nasal epithelium and mouse nasal mucosa.

  4. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 (show DHX58 Antibodies) associated MDA5 in virally-infected cells.

  5. embryonic death and phenotypes of Adar1 (show ADAR Antibodies)(E861A/E861A) were rescued by concurrent deletion of the cytosolic sensor of dsRNA, MDA5.

  6. IFIH1 heterozygous mice have a regulatory rather than effector T-cell response at the site of autoimmunity, supporting IFIH1 expression as an essential regulator of the diabetogenic T-cell response.

  7. Our results, therefore, suggest that Arl5B (show ARL5B Antibodies) is a negative regulator for MDA5.

  8. TRIM13 (show TRIM13 Antibodies) interacts with MDA5 and negatively regulates MDA5-mediated type I IFN production

  9. RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication.

  10. MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung.

Pig (Porcine) Interferon Induced with Helicase C Domain 1 (IFIH1) interaction partners

  1. These data indicate that classical swine fever virus can be recognized by both RIG-I (show DDX58 Antibodies) and MDA5 to initiate the RIG-I (show DDX58 Antibodies) signaling pathway to trigger innate defenses against infection.

  2. crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase (show DNA2 Antibodies) fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation

  3. IFIH1 had only one nonsynonymous SNP in the helicase (show DNA2 Antibodies) domain.

Interferon Induced with Helicase C Domain 1 (IFIH1) Antigen Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents\; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.

Gene names and symbols associated with IFIH1

  • interferon induced with helicase C domain 1 (IFIH1) antibody
  • interferon induced with helicase C domain 1 (Ifih1) antibody
  • 9130009C22Rik antibody
  • Helicard antibody
  • Hlcd antibody
  • IDDM19 antibody
  • MDA-5 antibody
  • MDA5 antibody
  • RGD1560496 antibody
  • RLR-2 antibody

Protein level used designations for IFIH1

interferon-induced helicase C domain-containing protein 1 , melanoma differentiation associated protein-5 , melanoma differentiation-associated protein 5 , CADM-140 autoantigen , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-I-like receptor 2 , RNA helicase-DEAD box protein 116 , clinically amyopathic dermatomyositis autoantigen 140 kDa , helicard , helicase with 2 CARD domains , murabutide down-regulated protein , interferon induced with helicase C domain protein 1 , melanoma differentiation associated protein 5

GENE ID SPECIES
424185 Gallus gallus
459692 Pan troglodytes
702024 Macaca mulatta
64135 Homo sapiens
71586 Mus musculus
100101927 Sus scrofa
535490 Bos taurus
499801 Rattus norvegicus
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