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IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping Interferon Regulatory Factor 2 Antibodies (139) and Interferon Regulatory Factor 2 Kits (2) and many more products for this protein.
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In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1 (show APOL1 Proteins). Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.
Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2 (show RUNX3 Proteins), OCI/AML-3 (show RUNX2 Proteins), and THP-1 cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B (show INPP4B Proteins) contributes to the effects of IRF2 on apoptosis and growth of AML (show RUNX1 Proteins) cells. Thus, IRF2 serves as an important regulator in AML (show RUNX1 Proteins) by targeting INPP4B (show INPP4B Proteins).
miR (show MLXIP Proteins)-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.
It might play as a tumor suppressor by regulating P53 (show TP53 Proteins) signaling in gastric cancer.
the association of IRF2 with susceptibility to systemic lupus erythematosus
Data suggest that interferon (show IFNA Proteins) regulatory factors 1 and 2 (IRF1 (show IRF1 Proteins) and IRF2) may serve as potential targets of therapy.
miR (show MLXIP Proteins)-221 directly inhibits the expression of SOCS3 (show SOCS3 Proteins) and IRF2.
KGF (show FGF7 Proteins) could up-regulate IL-7 (show IL7 Proteins) expression through the STAT1 (show STAT1 Proteins)/IRF-1 (show IRF1 Proteins), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (show FGF7 Proteins) on the intestinal mucosal immune system.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK1 Proteins)
IRF2 overexpression protects against I/R injury by decreasing IRF1 (show IRF1 Proteins)-dependent injury and may represent a novel therapeutic strategy.
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
Chimeric IRF-2 binds with IRF (show TRIM63 Proteins)-E motif and VREbeta but not with VREalpha1.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (show IFNAR1 Proteins)-dependent manner and antibody production via up-regulation of Blimp-1 (show PRDM1 Proteins).
In mice doubly deficient forIRF-2 and CD1d (show CD1D Proteins), the overall memory phenotype T cell population is contrastingly enlarged.
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.
Irf2 has an important role in vitro in the regulation of COX-2 expression by LPS (show TLR4 Proteins).
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
regulatory factor 2
, interferon responsive factor 2
, interferon regulatory factor 2b