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Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Additionally we are shipping ISG20 Proteins (5) and ISG20 Kits (3) and many more products for this protein.
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Cow (Bovine) Polyclonal ISG20 Primary Antibody for WB - ABIN2778794
Horio, Murai, Inoue, Hamasaki, Tanaka, Ohgi: Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease. in FEBS letters 2004
Show all 2 references for ABIN2778794
Human Polyclonal ISG20 Primary Antibody for EIA, WB - ABIN952958
Hao, Yang: Cloning, eukaryotic expression of human ISG20 and preliminary study on the effect of its anti-HBV. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008
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Human Monoclonal ISG20 Primary Antibody for IF, ELISA - ABIN561532
Möller, Pion, Narayan, Ball: Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain. in The Journal of biological chemistry 2010
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Cow (Bovine) Polyclonal ISG20 Primary Antibody for WB - ABIN2778795
Urlaub, Wöber: Identification of isoamylase, a glycogen-debranching enzyme, from Bacillus amyloliquefaciens. in FEBS letters 1975
Show all 2 references for ABIN2778795
The results suggest that hantavirus infection interferes with DAXX (show DAXX Antibodies)-mediated apoptosis, and expression of interferon-activated (show MNDA Antibodies) Sp100 (show SP100 Antibodies) and ISG-20 proteins may indicate intracellular intrinsic antiviral attempts.
ISG20 inhibited infections by hepatitis C virus, bovine viral diarrhea virus and hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus.
ISG20has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2'-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates
ISG20 has a role in reducing the synthesis of HBV proteins
Suggest that the recruitment of peripheral CXCR4 (show CXCR4 Antibodies)-expressing ITGA2 (show ITGA2 Antibodies)(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance.
Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. May be involved in the antiviral function of IFN against RNA viruses (By similarity). Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity).
interferon stimulated exonuclease gene 20kDa
, interferon stimulated exonuclease 20
, interferon stimulated gene 20kDa
, interferon-stimulated gene 20 kDa protein
, interferon-stimulated protein
, estrogen-regulated transcript 45 protein
, promyelocytic leukemia nuclear body-associated protein ISG20
, interferon stimulated exonuclease