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Interferon-Induced Transmembrane Protein 3 Proteins (IFITM3)

The protein encoded by IFITM3 is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Additionally we are shipping Interferon-Induced Transmembrane Protein 3 Antibodies (38) and Interferon-Induced Transmembrane Protein 3 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IFITM3 66141 Q9CQW9
IFITM3 10410 Q01628
Rat IFITM3 IFITM3 361673 P26376
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Top Interferon-Induced Transmembrane Protein 3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$272.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His-GST 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Log in to see 5 to 7 Days
$317.63
Details

IFITM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,

Top referenced Interferon-Induced Transmembrane Protein 3 Proteins

  1. Human IFITM3 Protein expressed in Wheat germ - ABIN1307445 : Yao, Dong, Zhu, Nelson, Liu, Lambiase, Li: Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line. in Journal of viral hepatitis 2011 (PubMed)

  2. Human IFITM3 Protein expressed in Human Cells - ABIN2005209 : Tanaka, Yamaguchi, Tsoi, Lickert, Tam: IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. in Developmental cell 2005 (PubMed)

More Proteins for Interferon-Induced Transmembrane Protein 3 (IFITM3) Interaction Partners

Mouse (Murine) Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.

  2. Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.

  3. results suggest that modification of Tyr (show TYR Proteins)(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3

  4. Interferon-induced transmembrane protein 3 is a type II transmembrane protein (show SLC3A2 Proteins).

  5. results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula

  6. Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines.

  7. Jin Chai antiviral capsule exerts antiviral effects against influenza virus by raised expression of IFITM3.

  8. lung TRM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures

  9. A central role for Ifitm3 in limiting acute influenza in vivo.

  10. IFITM3 is essential for defending the host against influenza A virus in vivo; mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 'Spanish' influenza

Human Interferon-Induced Transmembrane Protein 3 (IFITM3) interaction partners

  1. IFITM2 (show IFITM2 Proteins) and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env (show ERVW-1 Proteins)), thereby inhibiting viral infection.

  2. we demonstrate that the E3 ubiquitin ligase (show MUL1 Proteins) NEDD4 (show NEDD4 Proteins) ubiquitinates IFITM3 in cells and in vitro.

  3. Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza susceptibility, but not in mild influenza subjects

  4. A novel association between IFITM3 gene polymorphism and rapid disease progression is reported in an acute HIV-1-infected MSM cohort in China.

  5. This meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.

  6. Incorporation of IFITM1 (show IFITM1 Proteins), IFITM2 (show IFITM2 Proteins) and IFITM3 into HIV-1 virions impair viral fusion and spread.

  7. Authors suggest that IFITM3 adopts multiple membrane topologies involving at least one intramembrane domain in its antivirally active conformation.

  8. Taken together, these data suggested that IFITM3 is a potential therapeutic target for GC.

  9. Tyrosine 20 partially regulates the subcellular localization of IFITM3 but is not functionally essential for IFITM3-mediated H1N1 restriction.

  10. Host IFITM3,IFITM2 (show IFITM2 Proteins) and IFITM1 (show IFITM1 Proteins) facilitate morphogenesis of the human cytomegalovirus assembly.

Interferon-Induced Transmembrane Protein 3 (IFITM3) Protein Profile

Protein Summary

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.

Gene names and symbols associated with IFITM3

  • Interferon-induced transmembrane protein 3 (ifm3)
  • interferon induced transmembrane protein 3 (Ifitm3)
  • interferon induced transmembrane protein 3 (IFITM3)
  • 1-8U protein
  • 1110004C05Rik protein
  • Cd225 protein
  • Cdw217 protein
  • DSPA2b protein
  • Fgls protein
  • IP15 protein
  • mil-1 protein
  • rat8 protein

Protein level used designations for IFITM3

Interferon-induced transmembrane protein 3 , dispanin subfamily A member 2b , fragilis protein , ifitm-like protein 1 , interferon-induced transmembrane protein 3 , interferon-inducible protein 15 , interferon-inducible protein 1-8U , interferon-inducible protein variant 10

GENE ID SPECIES
100305344 Oncorhynchus mykiss
66141 Mus musculus
10410 Homo sapiens
361673 Rattus norvegicus
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