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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (49) and IL27 Proteins (27) and many more products for this protein.
Showing 10 out of 143 products:
Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043836
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Polyclonal IL27 Primary Antibody for EIA, IF - ABIN500000
Hunter: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. in Nature reviews. Immunology 2005
The Serum IL-27 levels were negatively correlated with neuromyelitis optica spectrum disorders severity and spinal cord lesion length.
IL-27 gene rs153109 A/G SNP may be involved in susceptibility to BD in the Iranian population.
Serum IL-27 and IL-27-producing T cells, are involved in the pathogenesis of pemphigus.
The level of interleukin 27 is increased in peripheral blood mononuclear cells of patients with rheumatoid arthritis or osteoarthritis.
role of IL-27 in inflammation, cancer development and regulation and differentiation of immune cells.
The B cell response to IL-27 is modulated during B cell differentiation and varies depending on the mode of B cell activation (show BLNK Antibodies).
data showed that progressive MS patients had decreased plasma and mRNA expression levels of IL-27, suggesting that it might be involved in the pathophysiological process of multiple sclerosis
The rs153109 and rs17855750 IL-27 polymorphisms were associated with increased risk for renal cell carcinoma (show MOK Antibodies), suggesting an important role of IL-27 in nephrocarcinogenesis.
The results of the present study clearly demonstrate that the STAT3 (show STAT3 Antibodies) pathway triggered by anti-inflammatory IL-27 plays a role in protecting cardiomyocytes against GSC (show GSC Antibodies)-mediated damage.
study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 Antibodies) positively regulates LPS (show TLR4 Antibodies)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted.
IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3 (show STAT3 Antibodies)/Pim-1 (show PIM1 Antibodies) signaling pathway.
demonstrate that suppression mediated by interferon (show IFNA Antibodies) and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo
Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma (show IFNG Antibodies) and IL-27 production.
demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections
IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 (show IL10 Antibodies) and suppression of IL-17 (show IL17A Antibodies).
These data identify an IL-27/NFIL3 (show NFIL3 Antibodies) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3 (show HAVCR2 Antibodies), IL-10 (show IL10 Antibodies) and T-cell dysfunction.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27