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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (40) and IL27 Proteins (26) and many more products for this protein.
Showing 10 out of 152 products:
Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043836
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Polyclonal IL27 Primary Antibody for EIA, IF - ABIN500000
Hunter: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. in Nature reviews. Immunology 2005
Our results showed that the IL-27 2905T/G genotypes were associated with decreased the susceptibility and development of cervical cancer in Chinese Han population.
the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases.
Findings demonstrated that IL-27 and IL-27R (show IL27RA Antibodies) were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells
IL-27 attenuates epithelial-mesenchymal transition in alveolar epithelial cells in the absence or presence of TGF-beta1 (show TGFB1 Antibodies) through the JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) and TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signalling pathways.
results provided new insights into the effect of IL-27 on the TNF-alpha (show TNF Antibodies) mediated activation of human coronary artery endothelial cells in atherosclerotic vascular inflammation
The 153109 of the IL27 (show EBI3 Antibodies) gene may be associated with the susceptibility to CHD (show CHDH Antibodies), including atrial septal defect and ventricular septal defect.
It is biologically plausible that SNPs in IL-27 may have effect on individual susceptibility to pre-eclampsia.
IL-27 induced IDO (show IDO1 Antibodies) or PD-L1 (show CD274 Antibodies) expression in monocytes and in human PC3 (show PCSK1 Antibodies) prostate and A549 lung cancer cells
An IL-27/Lag3 (show LAG3 Antibodies) axis enhances Foxp3 (show FOXP3 Antibodies)+ regulatory T cell-suppressive function and therapeutic efficacy.
The Serum IL-27 levels were negatively correlated with neuromyelitis optica spectrum disorders severity and spinal cord lesion length.
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 Antibodies) positively regulates LPS (show TLR4 Antibodies)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted.
IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3 (show STAT3 Antibodies)/Pim-1 (show PIM1 Antibodies) signaling pathway.
demonstrate that suppression mediated by interferon (show IFNA Antibodies) and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo
Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma (show IFNG Antibodies) and IL-27 production.
demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections
IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 (show IL10 Antibodies) and suppression of IL-17 (show IL17A Antibodies).
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27