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IRX3 is a member of the Iroquois homeobox gene family (see IRX1\; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Additionally we are shipping IRX3 Antibodies (81) and many more products for this protein.
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Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis.
data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO Proteins) and represents a novel determinant of body mass and composition
IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes.
barH-like homeobox-2 (show BARHL2 Proteins) gene barhl2 (show BARHL2 Proteins) acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog (show SHH Proteins)
Irx3 is transcriptionally induced by the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway during anteroposterior patterning of the neural axis.
Irx3 is the first gene known to be necessary and sufficient to specify nephron segment fate in vivo.
Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1.
postnatal Irx3 activity can be repressed by Irx5 (show IRX5 Proteins)
Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins
Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth.
IRX3 is a member of the Iroquois homeobox gene family (see IRX1\; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998
iroquois homeobox protein 3
, iroquois-class homeodomain protein IRX-3
, Iroquois related homeobox 3
, homeodomain protein IRXB1
, iroquois-class homeodomain protein IRX-1
, Iroquois homeobox protein 3
, homeobox transcription factor iroquois 3
, iroquois type homeobox
, iroquois-class homeodomain protein irx-3