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ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Additionally we are shipping Isoprenylcysteine Carboxyl Methyltransferase Antibodies (51) and Isoprenylcysteine Carboxyl Methyltransferase Kits (3) and many more products for this protein.
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Human ICMT Protein expressed in Escherichia coli (E. coli) - ABIN667011
Kagan, McFadden, McFadden, OConnor, Clarke: Molecular phylogenetics of a protein repair methyltransferase. in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997
simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.
impact of Icmt on tumorigenic processes
Silencing ICMT in osteosarcoma cells decreas (show NOTCH1 Proteins)ed Notch1 signaling in (show PDX1 Proteins)response to stimulation with cell-surface ligands.
a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.
modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma (show ARHGEF16 Proteins) cells
ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.
findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (show RACGAP1 Proteins) methylation and activation and its downstream antiapoptotic signaling pathway.
These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras (show HRAS Proteins)- and B-Raf (show SNRPE Proteins)-induced malignancies.
ICMT inhibition induces endothelial cell apoptosis through GRP94 (show HSP90B1 Proteins)
Icmt traverses the Eendoplasmic reticulum membrane eight times, with both N and C termini disposed toward the cytosol and with a helix-turn-helix structure comprising transmembrane (TM) segments 7 and 8.
ICMT deficiency precisely phenocopied Notch1 (show NOTCH1 Proteins) deficiency in the Pdx1 (show PDX1 Proteins)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (show WNT2 Proteins) signaling.
inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.
, isoprenylcysteine carboxyl methyltransferase
, Isoprenylcysteine carboxyl methyltransferase
, prenylated protein carboxyl methyltransferase
, prenylcysteine carboxyl methyltransferase
, protein-S isoprenylcysteine O-methyltransferase
, farnesyl cysteine carboxyl methyltransferase
, prenylcysteine carboxyl methlytransferase