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ITCH encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. Additionally we are shipping ITCH Antibodies (73) and ITCH Kits (3) and many more products for this protein.
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Human ITCH Protein expressed in Escherichia coli (E. coli) - ABIN2003996
Marchese, Raiborg, Santini, Keen, Stenmark, Benovic: The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. in Developmental cell 2003
Show all 5 references for ABIN2003996
Itch monoubiquitinates SMN (show STMN1 Proteins) and monoubiquitination of SMN (show STMN1 Proteins) plays an important role in regulating its cellular localization.
miR (show MLXIP Proteins)-106b, which itself is down regulated in metastatic pancreatic cancer, directly interacts and inhibits ITCH expression.
LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels.
Cytomegalovirus UL42 induced the ubiquitination and degradation of human Itch in virus-infected fibroblasts, and was partially colocalized with p62 (show GTF2H1 Proteins), a ubiquitin-binding protein, and CD63 (show CD63 Proteins), a marker of lysosome and multivesicular bodies.
catalytic activity of Itch toward different SH3 domain-containing proteins was similar, except for beta-PIX (show ARHGEF7 Proteins) that was not readily ubiquitylated even though it could interact with an affinity comparable to those of other substrates tested
Cell proliferation of hepatocellular carcinoma cells mediated by miR (show MLXIP Proteins)-411, is through suppression of ITCH expression.
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
These observations indicate that ITCH is involved in the cytosolic quality control pathway and may help to explain how abnormal proteins are targeted by QC ubiquitin-protein ligases.
Results suggest that Itch is a positive regulator of the TGF-beta (show TGFB1 Proteins)-mediated Smad (show SMAD1 Proteins) signaling pathway via Smad7 (show SMAD7 Proteins) ubiquitination and protein degradation.
ITCH up-regulation and LATS1 down-regulation were closely associated with tumorigenesis and progression of SCC (show CYP11A1 Proteins)
ITCH targets TXNIP (show TXNIP Proteins) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (show TXN Proteins) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (show TNF Proteins) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (show TNF Proteins) signaling is genetically deleted.
ITCH modulates SIRT6 (show SIRT6 Proteins) and SREBP2 (show SREBF2 Proteins) to influence lipid metabolism and atherosclerosis in ApoE (show APOE Proteins) null mice
The E3 ubiquitin ligase (show MUL1 Proteins) Itch inhibits p38alpha (show MAPK14 Proteins) signaling and skin inflammation through the ubiquitylation of Tab1 (show TAB1 Proteins).
Ndfip1 (show NDFIP1 Proteins) regulates itch ligase activity and airway inflammation via UbcH7 (show UBE2L3 Proteins).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (show FOXP3 Proteins) expression independently of Itch.
identify Itch as a regulator of Oct4 (show POU5F1 Proteins) stability and transcriptional activity, establishing a functional link between an E3 ligase and the regulation of pluripotency
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy