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anti-Izumo Sperm-Egg Fusion 1 (IZUMO1) Antibodies

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Izumo Sperm-Egg Fusion 1 Proteins (6) and Izumo Sperm-Egg Fusion 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IZUMO1 284359 Q8IYV9
IZUMO1 73456 Q9D9J7
Anti-Rat IZUMO1 IZUMO1 499152 Q6AY06
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Top anti-Izumo Sperm-Egg Fusion 1 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rat Un-conjugated IF, IP, WB 100 μg Log in to see 7 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-IZUMO1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated Inhibition, IF, IHC, WB 100 μL Log in to see 7 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit HRP ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL Log in to see 3 to 4 Days
$157.06
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 3 to 4 Days
$157.06
Details

IZUMO1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)
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Top referenced anti-Izumo Sperm-Egg Fusion 1 Antibodies

  1. Mouse (Murine) Monoclonal IZUMO1 Primary Antibody for IF, IP - ABIN2452040 : Inoue, Kasahara, Ikawa, Okabe: Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. in PLoS ONE 2010 (PubMed)
    Show all 4 references for ABIN2452040

  2. Human Polyclonal IZUMO1 Primary Antibody for Inhibition, IF - ABIN2452041 : Inoue, Ikawa, Isotani, Okabe: The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. in Nature 2005 (PubMed)

More Antibodies against Izumo Sperm-Egg Fusion 1 Interaction Partners

Human Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction

  2. crystal structures of human IZUMO1 and JUNO in unbound and bound conformations

  3. these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein.

  4. human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamste (show IGSF11 Antibodies)r eggs [Izumo]

Mouse (Murine) Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. Robust IZUMO1-dependent adhesion of sperm with an oocyte accompanies the dimerization of IZUMO1.

  2. Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 (show CD9 Antibodies) accumulation in the intercellular contact area prior to fusion during mammalian fertilization.

  3. identification of folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg.

  4. 'IZUMO1 putative functional fragment (IZUMO1PFF) maintains binding ability on the egg surface of Cd9 (show CD9 Antibodies)(-/-) eggs. IZUMO1PFF is composed of an N-terminal unfolded structure and a C-terminal ellipsoidal helix dimer.

  5. Translocation of IZUMO1 during the fertilization process determined by time lapse imaging.

  6. four phosphopeptide changes came from Izumo1, the sperm-egg fusion protein, in the cytoplasmic segment of the protein. 2D-PAGE confirmed that Izumo1 is post-translationally modified during epididymal transit.

  7. co-localization of TMEM190 with IZUMO1 and complex formation with other sperm proteins.

  8. identified an IZUMO1-interacting protein in sperm, which was identified as testis specific (show AIF1 Antibodies) ACE (show ACE Antibodies) homologue ACE3.

  9. Results suggest that Izumo 1 might be involved in organizing or stabilizing a multiprotein complex essential for the function of the membrane fusion machinery.

  10. identification of a mouse sperm fusion-related antigen and show that the antigen is a novel immunoglobulin superfamily protein (show IGSF11 Antibodies)

Izumo Sperm-Egg Fusion 1 (IZUMO1) Antigen Profile

Protein Summary

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005

Gene names and symbols associated with IZUMO1

  • izumo sperm-egg fusion 1 (IZUMO1) antibody
  • izumo sperm-egg fusion 1 (LOC100358660) antibody
  • izumo sperm-egg fusion 1 (Izumo1) antibody
  • 1700058F15Rik antibody
  • Izumo antibody

Protein level used designations for IZUMO1

izumo sperm-egg fusion 1 , sperm-egg fusion 1-like , izumo sperm-egg fusion protein 1 , sperm-specific protein Izumo , sperm-egg fusion 1 , izumo sperm-egg fusion protein 1-like , OBF , oocyte binding/fusion factor , sperm-specific protein izumo

GENE ID SPECIES
618057 Bos taurus
718234 Macaca mulatta
747578 Pan troglodytes
100302705 Ovis aries
100358660 Oryctolagus cuniculus
100446925 Pongo abelii
100590428 Nomascus leucogenys
284359 Homo sapiens
73456 Mus musculus
499152 Rattus norvegicus
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