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Izumo Sperm-Egg Fusion 1 Proteins (IZUMO1)

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Izumo Sperm-Egg Fusion 1 Antibodies (23) and Izumo Sperm-Egg Fusion 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IZUMO1 284359 Q8IYV9
IZUMO1 73456 Q9D9J7
Rat IZUMO1 IZUMO1 499152 Q6AY06
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Top Izumo Sperm-Egg Fusion 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

IZUMO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,

More Proteins for Izumo Sperm-Egg Fusion 1 (IZUMO1) Interaction Partners

Human Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction

  2. crystal structures of human IZUMO1 and JUNO in unbound and bound conformations

  3. these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein.

  4. human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamste (show IGSF11 Proteins)r eggs [Izumo]

Mouse (Murine) Izumo Sperm-Egg Fusion 1 (IZUMO1) interaction partners

  1. Robust IZUMO1-dependent adhesion of sperm with an oocyte accompanies the dimerization of IZUMO1.

  2. Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 (show CD9 Proteins) accumulation in the intercellular contact area prior to fusion during mammalian fertilization.

  3. identification of folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg.

  4. 'IZUMO1 putative functional fragment (IZUMO1PFF) maintains binding ability on the egg surface of Cd9 (show CD9 Proteins)(-/-) eggs. IZUMO1PFF is composed of an N-terminal unfolded structure and a C-terminal ellipsoidal helix dimer.

  5. Translocation of IZUMO1 during the fertilization process determined by time lapse imaging.

  6. four phosphopeptide changes came from Izumo1, the sperm-egg fusion protein, in the cytoplasmic segment of the protein. 2D-PAGE confirmed that Izumo1 is post-translationally modified during epididymal transit.

  7. co-localization of TMEM190 with IZUMO1 and complex formation with other sperm proteins.

  8. identified an IZUMO1-interacting protein in sperm, which was identified as testis specific (show AIF1 Proteins) ACE (show ACE Proteins) homologue ACE3.

  9. Results suggest that Izumo 1 might be involved in organizing or stabilizing a multiprotein complex essential for the function of the membrane fusion machinery.

  10. identification of a mouse sperm fusion-related antigen and show that the antigen is a novel immunoglobulin superfamily protein (show IGSF11 Proteins)

Izumo Sperm-Egg Fusion 1 (IZUMO1) Protein Profile

Protein Summary

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005

Gene names and symbols associated with IZUMO1

  • izumo sperm-egg fusion 1 (IZUMO1)
  • izumo sperm-egg fusion 1 (LOC100358660)
  • izumo sperm-egg fusion 1 (Izumo1)
  • 1700058F15Rik protein
  • Izumo protein

Protein level used designations for IZUMO1

izumo sperm-egg fusion 1 , sperm-egg fusion 1-like , izumo sperm-egg fusion protein 1 , sperm-specific protein Izumo , sperm-egg fusion 1 , izumo sperm-egg fusion protein 1-like , OBF , oocyte binding/fusion factor , sperm-specific protein izumo

GENE ID SPECIES
618057 Bos taurus
718234 Macaca mulatta
747578 Pan troglodytes
100302705 Ovis aries
100358660 Oryctolagus cuniculus
100446925 Pongo abelii
100590428 Nomascus leucogenys
284359 Homo sapiens
73456 Mus musculus
499152 Rattus norvegicus
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