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The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Izumo Sperm-Egg Fusion 1 Antibodies (26) and Izumo Sperm-Egg Fusion 1 Kits (4) and many more products for this protein.
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crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction
crystal structures of human IZUMO1 and JUNO in unbound and bound conformations
these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein.
human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamste (show IGSF11 Proteins)r eggs [Izumo]
Five IZUMO BCE were identified: DLVLDCL177-183, YSFYRV196-201 (named BCE-2), YLT217-219, SMVGPED221-227, and DAGNY228-232. Active immunization with the BCE-2 vaccine sharply decreased the fertility rate in female mice in a safe and reversible manner.
Robust IZUMO1-dependent adhesion of sperm with an oocyte accompanies the dimerization of IZUMO1.
Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 (show CD9 Proteins) accumulation in the intercellular contact area prior to fusion during mammalian fertilization.
identification of folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg.
'IZUMO1 putative functional fragment (IZUMO1PFF) maintains binding ability on the egg surface of Cd9 (show CD9 Proteins)(-/-) eggs. IZUMO1PFF is composed of an N-terminal unfolded structure and a C-terminal ellipsoidal helix dimer.
Translocation of IZUMO1 during the fertilization process determined by time lapse imaging.
four phosphopeptide changes came from Izumo1, the sperm-egg fusion protein, in the cytoplasmic segment of the protein. 2D-PAGE confirmed that Izumo1 is post-translationally modified during epididymal transit.
co-localization of TMEM190 with IZUMO1 and complex formation with other sperm proteins.
identified an IZUMO1-interacting protein in sperm, which was identified as testis specific (show AIF1 Proteins) ACE (show ACE Proteins) homologue ACE3.
Results suggest that Izumo 1 might be involved in organizing or stabilizing a multiprotein complex essential for the function of the membrane fusion machinery.
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005
izumo sperm-egg fusion 1
, sperm-egg fusion 1-like
, izumo sperm-egg fusion protein 1
, sperm-specific protein Izumo
, sperm-egg fusion 1
, izumo sperm-egg fusion protein 1-like
, oocyte binding/fusion factor
, sperm-specific protein izumo