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Required for normal cytokinesis during mitosis. Additionally we are shipping Jumping Translocation Breakpoint Antibodies (18) and Jumping Translocation Breakpoint Kits (5) and many more products for this protein.
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Human JTB Protein expressed in Human Cells - ABIN2005713
Platica, Chen, Ivan, Lopingco, Holland, Platica: PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. in International journal of oncology 2000
Show all 2 references for ABIN2005713
Downregulation of the PAR expression increases the Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins) ratio and Bax (show BAX Proteins) expression, and thus induces the G2-M phase arrest and apoptosis of PC3 (show PCSK1 Proteins) cells.
Silencing of the JTB resulted in an increase in the phosphorylation of p65 (show GORASP1 Proteins) in HepG2 cells.
The JTB structure has a distant relationship to the midkine (show MDK Proteins)/pleiotrophin (show PTN Proteins) fold, particularly in the conservation of distinctive disulfide bridge patterns.
Due to its involvement in cell cycle and its overexpression in several human cancers PAR could represent an attractive target for therapeutic intervention.
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1 (show SHC1 Proteins), CCT3 (show CCT3 Proteins) and COPA (show COPA Proteins) in the tumors than the paired adjacent non-malignant liver tissues.
Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
jumping translocation breakpoint
, protein JTB
, jumping translocation breakpoint protein
, prostate androgen-regulated protein