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The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. Additionally we are shipping Jun D Proto-Oncogene Antibodies (162) and Jun D Proto-Oncogene Proteins (8) and many more products for this protein.
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identify AP-1(JunD/c-Fos) as a novel hematopoietic transcription factor and the requirement of AP-1(JunD/c-Fos) in BMP-4 (show BMP4 ELISA Kits)-induced hematopoiesis during Xenopus hematopoiesis.
In T cells, after serum deprivation HBZ (show HBZ ELISA Kits) induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ (show HBZ ELISA Kits) bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia .
MiR (show MLXIP ELISA Kits)-663a suppresses proliferation and invasion by targeting AP-1 (show FOSB ELISA Kits) component JunD in non-small cell lung cancer cells.
studies showed that down-regulation of JunD in response to TGF-beta (show TGFB1 ELISA Kits) treatment is mediated via the proteasomal degradation pathway.
CARMA1 (show CARD11 ELISA Kits)- and MyD88 (show MYD88 ELISA Kits)-dependent activation of Jun (show JUN ELISA Kits)/ATF-type AP-1 (show FOSB ELISA Kits) complexes is a hallmark of ABC (show ABCB6 ELISA Kits) diffuse large B-cell lymphomas.
recombinant SERPINE2 (show SERPINE2 ELISA Kits) induced a clear inhibition of MMP-13 (show MMP13 ELISA Kits) expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1 (show MAPK3 ELISA Kits)/2, NF-kappaB (show NFKB1 ELISA Kits) and AP-1 (show FOSB ELISA Kits)
miR (show MLXIP ELISA Kits)-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha (show TNF ELISA Kits)
JunD activates miR (show MLXIP ELISA Kits)-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
Binding of specific AP-1 (show FOSB ELISA Kits) factors, we found JunD associated with the LILRB1 (show LILRB1 ELISA Kits) distal promoter.
Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3 (show TGFBR3 ELISA Kits)- JUND expression.
BAG3 (show BAG3 ELISA Kits) stabilized JunD mRNA.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (show JUN ELISA Kits) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
JunD provides protection in aging-induced endothelial dysfunction and may represent a novel target to prevent reactive oxygen species-driven vascular aging.
AP-1 (show JUN ELISA Kits) composed with JunD and Fra2 (show FOSL2 ELISA Kits) protein plays a primary role in enhancing the transcription level of the CD11c (show ITGAX ELISA Kits) gene in dendritic cells
Nfe2 (show NFE2 ELISA Kits) modulates JunD binding to the Gcm1 (show GCM1 ELISA Kits) promoter via acetylation
5-HT2B (show HTR2B ELISA Kits) blockade enhances liver regeneration by inhibiting induction of TGF-beta1 (show TGFB1 ELISA Kits) expression by hepatic stellate cells that is dependent on 5-HT (show DDC ELISA Kits), ERK (show EPHB2 ELISA Kits) and JunD.
CDK4 (show CDK4 ELISA Kits)-mediated regulation of cell functions via c-Jun (show JUN ELISA Kits) phosphorylation and AP-1 (show JUN ELISA Kits) activation
Downregulation of JunD and cyclin D1 (show CCND1 ELISA Kits) expression in myofibroblasts may be important regarding the mechanism of action of MTA (show DNMT1 ELISA Kits) in Mdr2 (show ABCB4 ELISA Kits)-/- mice
c-Jun (show JUN ELISA Kits), JunB (show JUNB ELISA Kits), and JunD are not functionally equivalent and have both overlapping and independent functions in controlling cellular proliferation, cell-cycle arrest/senescence and the response to stress.
Study supports potential roles for jun (show JUN ELISA Kits) D, jun (show JUN ELISA Kits) B, and fra-1 (show FOSL1 ELISA Kits) in the dietary energy restriction regulation of AP-1 (show JUN ELISA Kits) function in the Sencar mouse skin carcinogenesis model.
protects cells from p53 (show TP53 ELISA Kits)-dependent senescence and apoptosis
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage, including non-AUG codons, results in the production of different isoforms.
transcription factor jun-D
, JunD-FL isoform
, activator protein 1
, Jun proto-oncogene related gene d1