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Junctional Adhesion Molecule 3 Proteins (JAM3)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping JAM3 Antibodies (84) and JAM3 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JAM3 83964 Q9D8B7
JAM3 83700 Q9BX67
Rat JAM3 JAM3 315509 Q68FQ2
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Top JAM3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 9 to 11 Days
$396.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
Details

JAM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , ,
, , , ,

Top referenced JAM3 Proteins

  1. Mouse (Murine) JAM3 Protein expressed in Human Cells - ABIN2007836 : Breunig, Mackedonski, Hollenberg: Transcription of the bacterial beta-lactamase gene in Saccharomyces cerevisiae. in Gene 1983 (PubMed)
    Show all 2 references for ABIN2007836

  2. Human JAM3 Protein expressed in Human Cells - ABIN2005501 : Arrate, Rodriguez, Tran, Brock, Cunningham: Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for ABIN2005501

  3. Human JAM3 Protein expressed in Escherichia coli (E. coli) - ABIN1098402 : Santoso, Sachs, Kroll, Linder, Ruf, Preissner, Chavakis: The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. in The Journal of experimental medicine 2002 (PubMed)

More Proteins for Junctional Adhesion Molecule 3 (JAM3) Interaction Partners

Zebrafish Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. interaction between Jamb (show JAM2 Proteins) and Jamc expressed by neighbouring cells is essential for fusion. jamc is ectopically expressed in prdm1a (show PRDM1 Proteins) mutant slow muscle precursors, which inappropriately fuse with other myocytes.

Mouse (Murine) Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils.

  2. Endothelial-specific deletion of JAM-C promoted endothelial cell sprouting, and consequently vessel normalisation and revascularisation of the hypoxic retina without altering pathologic neovascularisation.

  3. JAM-C blockade can finely-tune the innate cell migration and accelerate the consequent immune response to L. major without changing the type of the T helper cell response.

  4. Function of Jam-B (show JAM2 Proteins)/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

  5. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer.

  6. JAM-C might be involved in the final steps of trafficking and transmigration of antigen-specific autoaggressive T-cells to the islets of Langerhans.

  7. study suggests that JAM-C(-/-) C57BL/6 mice model the important role for JAM-C in brain development and CSF (show CSF2 Proteins) homeostasis as recently observed in humans with a loss-of-function mutation in JAM-C

  8. Data show that junctional adhesion molecule-B (JAM-B (show JAM2 Proteins)) expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with junctional adhesion molecule-C (JAM-C) on tumor cells.

  9. Results indicate that in vivo JAM-C shows enrichment at the apical surface and therefore is asymmetrically distributed during cell divisions.

  10. Data indicate deletion of JAM-C in deletion of JAM-C in Schwann cells (SCs (show TWIST1 Proteins)) (JAM-C SC KO) mice showed electrophysiological defects, muscular weakness, and hypersensitivity to mechanical stimuli.

Human Junctional Adhesion Molecule 3 (JAM3) interaction partners

  1. Palmitoylation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549 lung cancer cells.

  2. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils.

  3. Suggest JAM3-M4 methylation as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix.

  4. JAM-C inactivation in endothelial cells resulted in increased spreading on fibronectin and enhanced sprouting in vitro in a manner dependent on beta1-integrin and on the activation of the small GTPase RAP1.

  5. Function of Jam-B (show JAM2 Proteins)/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

  6. indicate that JAM-C may be a therapeutic target for preventing and treating lymphatic metastases

  7. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer.

  8. Our study confirms the importance of JAM3 as a component of the junctional complexes and its deficiency leading to a distinctive and catastrophic neonatal presentation of cataracts and hemorrhagic destruction of the brain.

  9. These data brought new evidences for the role of JAM2 (show JAM2 Proteins) and JAM3 in progression of gastric adenocarcinoma

  10. In the present study, we investigated the role of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodeficient mouse model.

JAM3 Protein Profile

Protein Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with JAM3

  • junctional adhesion molecule 3 (JAM3)
  • junctional adhesion molecule 3b (jam3b)
  • si:ch211-277g22.3 (si:ch211-277g22.3)
  • junction adhesion molecule 3 (Jam3)
  • junctional adhesion molecule 3 (Jam3)
  • 1110002N23Rik protein
  • JAM-2 protein
  • JAM-3 protein
  • JAM-C protein
  • jam3 protein
  • JAMC protein
  • jamc.2 protein
  • Jcam3 protein
  • sr:nyz155 protein
  • wu:fb30h11 protein
  • wu:fc08c06 protein
  • wu:fc13e04 protein
  • wu:fc25g11 protein

Protein level used designations for JAM3

junctional adhesion molecule 3 , jamc , jamc.1 , si:ch211-277g22.3 , JAM-C-like protein , junction cell adhesion molecule 3 , junction cell adhesion molecule C , junctional adhesion molecule C , JAM-3 , JAM-C

GENE ID SPECIES
419736 Gallus gallus
451678 Pan troglodytes
569217 Danio rerio
797651 Danio rerio
83964 Mus musculus
83700 Homo sapiens
489271 Canis lupus familiaris
513412 Bos taurus
315509 Rattus norvegicus
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