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The protein encoded by KIAA1530 appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. Additionally we are shipping KIAA1530 Proteins (3) and many more products for this protein.
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Human Polyclonal KIAA1530 Primary Antibody for ICC, IF - ABIN442562
Nakazawa, Sasaki, Mitsutake, Matsuse, Shimada, Nardo, Takahashi, Ohyama, Ito, Mishima, Nomura, Kinoshita, Ono, Takenaka, Masuyama, Kudo, Slor, Utani, Tateishi, Yamashita, Stefanini, Lehmann, Yoshiura et al.: Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. ... in Nature genetics 2012
Show all 2 Pubmed References
stabilization of UVSSA by interaction with USP7 (show USP7 Antibodies) is essential for Transcription-coupled Nucleotide Excision Repair
UVSSA together with USP7 (show USP7 Antibodies) is implicated in regulating transcription-coupled DNA repair.[review]
Human UVSSA protein is required for the ubiquitination of RNA polymerase and DNA repair after light-induced DNA damage [review].
KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome.
Mutations in the UVSSA gene is associated with UV-sensitive syndrome.
Mutations in UVSSA cause UV-sensitive syndrome and recruits USP7 (show USP7 Antibodies) to regulate transcription-coupled repair.
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 (show ERCC6 Antibodies) in transcription-coupled DNA repair.
The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3.
UV-stimulated scaffold protein A