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KAZ encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. Additionally we are shipping Kazrin Antibodies (38) and many more products for this protein.
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exons 5-15 of kazrin, encoding the nuclear localization signal and C-terminal domain, are not required for epidermal development and function
kazrinE is a kazrin isoform with a liprin-homology domain(LHD), and associates with stabilised microtubules via its LHD. Overexpressed kazrinE in epidermal keratinocytes induces changes in cell shape and stimulates terminal differentiation.
Kazrin colocalizes with periplakin (show PPL Proteins) and desmoplakin at desmosomes and with periplakin (show PPL Proteins) at the interdesmosomal plasma membrane, but its subcellular distribution is independent of periplakin (show PPL Proteins) [kazrin]
kazrin is a dual regulator of intercellular adhesion and differentiation in keratinocytes and regulates these processes by Rho-dependent and -independent mechanisms
These results suggested that Kazrin F might play an important role in regulating cellular apoptosis by interacting with ARC (show NOL3 Proteins) and Bax (show BAX Proteins).
This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified.