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Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Kits (9) and Kinase Suppressor of Ras 1 Proteins (7) and many more products for this protein.
Showing 10 out of 102 products:
Mouse (Murine) Monoclonal KSR1 Primary Antibody for IF, WB - ABIN968599
Michaud, Therrien, Cacace, Edsall, Spiegel, Rubin, Morrison: KSR stimulates Raf-1 activity in a kinase-independent manner. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 4 references for ABIN968599
Mouse (Murine) Polyclonal KSR1 Primary Antibody for WB - ABIN658071
Razidlo, Johnson, Stoeger, Cowan, Bessho, Lewis: KSR1 is required for cell cycle reinitiation following DNA damage. in The Journal of biological chemistry 2009
Human Polyclonal KSR1 Primary Antibody for EIA, IHC (p) - ABIN360141
Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001
Human Polyclonal KSR1 Primary Antibody for IHC (p), WB - ABIN392257
Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001
the atypical C1 domain, the CC-SAM (show TTN Antibodies) domain is required to target KSR-1 to the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 Antibodies) module.
Review discusses the possibility that KSR, a RAF (show ARAF Antibodies)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 Antibodies) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 Antibodies)-like proteins.
Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
propose that phosphorylation of Tyr (show TYR Antibodies)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
Data indicate that phosphorylation of BRAF (show BRAF Antibodies) by AMPK (show PRKAA1 Antibodies) disrupts its association with KSR1.
Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 Antibodies)-dependent T cell differentiation.
Ksr1 plays a dispensable role in lipopolysaccharide (LPS (show TLR4 Antibodies))-induced ERK (show EPHB2 Antibodies) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (show TLR4 Antibodies) model.
The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 Antibodies) pathway signaling leading to increased Myc (show MYC Antibodies)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
a model whereby MARK2 (show MARK2 Antibodies) negatively regulates insulin (show INS Antibodies) sensitivity in peripheral tissue through inhibition of KSR1
Genetic disruption of KSR1 results in striking reductions in kit-ligand (show KITLG Antibodies)-mediated proliferation & degranulation and impacts the biochemical activation of p21 (show D4S234E Antibodies)-activated kinase.
Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 (show MAPK1/3 Antibodies) signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.
Upregulation of KSR1 is associated with Colorectal cancer.
the relative mRNA copy values of KSR1, ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 (show MAPK1/3 Antibodies) pathway in gastric cancer
KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 Antibodies)+ BC treated with adjuvant TAM (show CCNA1 Antibodies).
KSR1 is coordinately regulated with Notch (show NOTCH1 Antibodies) signaling and oxidative phosphorylation in papillary thyroid cancer.
KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 Antibodies) abundance and increased BRCA1-BARD1 (show BARD1 Antibodies) interaction
Our findings integrate KSR1 into a network involving DBC1 (show DBC1 Antibodies) and SIRT1 (show SIRT1 Antibodies), which results in the regulation of p53 (show TP53 Antibodies) acetylation and its transcriptional activity.
Elevated levels of phosphorylated KSR were detected in the nuclear fractions.
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
, kinase suppressor of Ras85D
, suppressor of Ras1 3-1
, kinase suppressor of Ras 1
, protein Hb