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Transcription repressor that binds to the promoter of target genes and prevents their expression. Additionally we are shipping KLF17 Kits (20) and KLF17 Proteins (3) and many more products for this protein.
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Human Polyclonal KLF17 Primary Antibody for FACS, WB - ABIN651698
Gumireddy, Li, Gimotty, Klein-Szanto, Showe, Katsaros, Coukos, Zhang, Huang: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. in Nature cell biology 2009
Show all 2 references for ABIN651698
Data suggest that Neptune is a new member of hatching gland specifier and plays a physiological role in determination and specification of multiple lineages derived from the NPB (show NPB Antibodies) region.
Suggest that KLF17 inhibits esophageal carcinoma development and may serve as a potential therapeutic target.
Enhanced KLF17 expression sensitizes ERalpha (show ESR1 Antibodies)-positive breast cancer cells to endocrine therapy.KLF17-ERalpha (show ESR1 Antibodies) interaction plays a potential role in inhibition of ERalpha (show ESR1 Antibodies)-dependent breast cancer progression.
KLF17 empowers TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling by targeting Smad3 (show SMAD3 Antibodies)-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Tumor-suppressive p53 (show TP53 Antibodies) signaling is critical for KLF17 to inhibit cancer metastasis in Non-small Cell Lung Cancer.
A small subset of Myoepithelial tumors harbor FUS (show FUS Antibodies) rearrangements, two thirds of them being associated with KLF17 fusion.
In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC (show FAM126A Antibodies), summarize key pathways, and propose areas for further investigation
The reduced expression of KLF17 promoted the motility and proliferation ability of TPC1 (show TPCN1 Antibodies) cells by altering the expression of tight junction protein 1 (show TJP1 Antibodies) and Snai1 (show SNAI1 Antibodies), and activating the AKT (show AKT1 Antibodies) pathway by upregulating inhibitor of DNA binding 1 (show ID1 Antibodies).
mutant p53 (show TP53 Antibodies) enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells
The reduced expression of KLF17 protein in gastric cancer was correlated with tumor size, pN stage and lymphovascular invasion and was an independent predictor for poor survival in patients undergoing surgery for gastric cancer.
KLF17 might be one of the downstream signalling molecules of DJ-1 (show PARK7 Antibodies).
ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development
demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 (show ID1 Antibodies) can serve as a potential biomarker for lymph node metastasis in breast cancer
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
Kruppel-like factor 17
, Kruppel-like transcription factor neptune
, novel kruppel-like factor family protein
, krueppel-like factor 17-like
, Krueppel-like factor 17
, novel zinc-finger protein
, zinc finger protein 393
, germ cell specific zinc finger protein
, germ cell-specific zinc finger protein