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KLF14 encodes a member of the Kruppel-like family of transcription factors. Additionally we are shipping KLF14 Antibodies (24) and KLF14 Proteins (4) and many more products for this protein.
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SNPs at the CETP (show CETP ELISA Kits), HNF4A (show HNF4A ELISA Kits) and KLF14 (show SP6 ELISA Kits) locus are associated with HDL (show HSD11B1 ELISA Kits)-C levels and type 2 diabetes (in female participants).
KLF14 (show SP6 ELISA Kits) plays an important role in increasing glucose uptake and insulin (show INS ELISA Kits) sensitivity by the activation of PI3-kinase (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway in vitro.
KLF14 (show SP6 ELISA Kits) transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exis (show SP6 ELISA Kits)ts an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.
Trans (show SP6 ELISA Kits)duction of HepG2 cells with human KLF14 showed that KLF14 is a regu (show SP6 ELISA Kits)lator of APOA1 expres (show HSD11B1 ELISA Kits)sion.
The risk allele C of rs151290 in KCNQ1 (show KCNQ1 ELISA Kits) and risk allele G of rs972283 in KLF14 (show SP6 ELISA Kits) were both associated with increased risk of T2DM in a global population.
This is the first description of the activity and mechanisms underlying the function of KLF14 (show SP6 ELISA Kits) as an activator protein and novel regulator of lipid signaling.
The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.
we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis (show CISH ELISA Kits)-acting expression quantitative trait locus (eQTL (show EQTN ELISA Kits)) of the maternally expressed transcription factor KLF14 (show SP6 ELISA Kits) acts as a master trans regulator of adipose gene expression
KLF14 (show SP6 ELISA Kits) gene is imprinted, with preferential expression from the maternal allele.
the TGFbeta (show TGFB1 ELISA Kits) pathway activation leads to recruitment of a KLF14 (show SP6 ELISA Kits)-mSin3A-HDAC2 (show HDAC2 ELISA Kits) repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.
These data demonstrate an important role for KLF14 (show SP6 ELISA Kits) expression in atherosclerotic lesion formation.
KLF14 (show SP6 ELISA Kits) reduction serves as a mechanism leading to centrosome amplification and tumorigenesis. On the other hand, forced expression of KLF14 (show SP6 ELISA Kits) leads to mitotic catastrophe.
KLF14 (show SP6 ELISA Kits) is dysregulated in the liver of 2 dyslipidemia mouse models. KLF14 (show SP6 ELISA Kits) regulates plasma HDL (show HSD11B1 ELISA Kits)-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I (show APOA1 ELISA Kits) production. Hepatic-specific Klf14 (show SP6 ELISA Kits) deletion in mice decreased circulating HDL (show HSD11B1 ELISA Kits)-C levels.
The presence of progesterone induced the gene expression of egr-1 (show EGR1 ELISA Kits) and also KLF14 (show SP6 ELISA Kits), indicating that this steroid channels the signaling pathway into a non-canonical mechanism.
KLF14 (show SP6 ELISA Kits) gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse.
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
BTE-binding protein 5
, Krueppel-like factor 14
, basic transcription element-binding protein 5
, transcription factor BTEB5