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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) Antibodies

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LATS2 50523 Q7TSJ6
LATS2 305922  
LATS2 26524 Q9NRM7
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Top anti-LATS2 Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with LATS2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. The anti-LATS2 Pab is used in Western blot to detect LATS2 in NIH/3T3 cell lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using LATS2 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using LATS2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-LATS2 Pab (ABIN391034) is used in Western blot to detect LATS2 in NIH/3T3 cell lysate. Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with LATS2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, PLA, WB Detection of Human LATS2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP loaded/lane) from HeLa cells. Antibodies: ABIN152335 used at 0.4 mcg/ml (A) and 1 mcg/ml (B) for WB and at 3 mcg/mg lysate for IP. LATS2 was also immunoprecipitated by another LATS2 antibody, which is an affinity purified antibody to a downstream epitope from LATS2. Detection: Chemiluminescence with an exposure time of 30 seconds (A and B). Proximity Ligation Assay: LATS2 Antibody [ABIN152335] - Secondary-conjugate Duolink In Situ PLA in Hela cells. goat anti-human CHK1 (ABIN152335) and rabbit anti-human LATS2 (ABIN152335). Image merged from DAPI (2ms), FITC/Green (25ms) and TRITC/Orange (250ms) exposures, 40X magnification. 100 μL Log in to see 5 to 7 Days
$486.94
Details
Mouse Rabbit Un-conjugated WB Mouse Lats2 Antibody (C-term) (ABIN1881491) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the Mouse Lats2 antibody detected the Mouse Lats2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti phospho-LATS2 (Ser83) Polyclonal Antibody, Unconjugated (ABIN753568) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti-LATS2 (Ser83) Polyclonal Antibody, Unconjugated  at 1:300 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$291.50
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat heart labeled with Anti LATS2 Polyclonal Antibody, Unconjugated (ABIN753553) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti-LATS2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details

LATS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LATS2 Antibodies

  1. Human Polyclonal LATS2 Primary Antibody for IP, PLA - ABIN152335 : Kilili, Kyriakis et al.: Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 ... in The Journal of biological chemistry 2010 (PubMed)
    Show all 14 references for ABIN152335

  2. Mouse (Murine) Polyclonal LATS2 Primary Antibody for IHC, WB - ABIN350433 : Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005 (PubMed)
    Show all 5 references for ABIN350433

  3. Mouse (Murine) Polyclonal LATS2 Primary Antibody for WB - ABIN1881491 : Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. in Molecular and cellular biology 2009 (PubMed)
    Show all 4 references for ABIN1881491

  4. Human Polyclonal LATS2 Primary Antibody for IF, IHC - ABIN1534144 : Hori, Takaori-Kondo, Kamikubo, Uchiyama: Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. in Oncogene 2000 (PubMed)
    Show all 3 references for ABIN1534144

  5. Human Polyclonal LATS2 Primary Antibody for IHC (p), WB - ABIN391034 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)

  6. Human Polyclonal LATS2 Primary Antibody for EIA, IHC (p) - ABIN359092 : Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001 (PubMed)

More Antibodies against LATS2 Interaction Partners

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) displayed constitutive SREBP activation and overexpressed SREBP target genes and developed spontaneous fatty liver disease

  2. protein and mRNA expression of the MST1 (show MST1 Antibodies) and LATS2 were decreased significantly as mouse age increased (p < 0.05), however, the mRNA expression of them increased significantly in 16 m compared with 5 m as well as the protein expression of LATS2.

  3. Lats2 is recruited to the p53 (show TP53 Antibodies) pathway to coordinate proper transcriptional reprogramming.

  4. Lats2 regulates the balance between proliferation and differentiation during adipose development.

  5. miR (show MLXIP Antibodies)-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene.

  6. KIBRA (show WWC1 Antibodies) associates with and activates Lats (large tumor suppressor (show LATS1 Antibodies)) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  7. Lats2 plays an essential mitotic role in coordinating accurate cytokinesis completion, governing the stabilization of other mitotic regulators

  8. Lats2 affects both growth and death of cardiac myocytes, but it primarily regulates the size of the heart and acts as an endogenous negative regulator of cardiac hypertrophy.

Human LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. LATS2 was found to have binding sites for miR (show MLXIP Antibodies)-135b in the 3'UTR (show UTS2R Antibodies) region and results demonstrated that LATS2 is a direct target of miR (show MLXIP Antibodies)-135b which regulates its expression in breast cancer cells.

  2. Characterisation of LATS2 variants uncovers novel insights into the regulation of LATS (show LATS1 Antibodies) kinases in Hippo signalling.

  3. LATS2 could be induced by TNF-alpha (show TNF Antibodies) and inhibited cell proliferation and invasion by phosphorylating YAP (show YAP1 Antibodies) in OSCC cells.

  4. our current data indicated a new regulatory mechanism of YAP1 (show YAP1 Antibodies) by the LATS2-mediated phosphorylation that was involved in hepatocellular carcinoma tumorigenesis.

  5. Mutation in LATS2 gene is associated with malignant peritoneal mesothelioma.

  6. Phosphorylation of CHO1 (show KIF23 Antibodies) at S716 by Lats2 regulate its centrosomal localization, and that phosphorylated CHO1 (show KIF23 Antibodies) interacts with and activates LIMK1 (show LIMK1 Antibodies) during early mitosis.

  7. Loss of LATS2 expression is associated with lung cancer.

  8. results reported here further support that LATS1 (show LATS1 Antibodies)/2 act normally as tumor suppressors and loss of their functions contributes to human cancer development

  9. Phosphorylation of S716 NDR (show STK38 Antibodies)/LATS (show LATS1 Antibodies), present only in the longest Kif23 (show KIF23 Antibodies) isoform, is required for phosphorylation at S814, revealing phosphorylation at these two sites, and differential regulation of Kif23 (show KIF23 Antibodies)-14-3-3 (show YWHAQ Antibodies) interaction for the two Kif23 (show KIF23 Antibodies) isoforms.

  10. LATS1 (show LATS1 Antibodies) and LATS2 kinases play an important role in the regulation of NS5A function through site-specific post-translational modification and that phosphorylation of Ser (show SIGLEC1 Antibodies)/Thr71 is essential for optimal viral genome replication.

Zebrafish LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. Thus AMOT (show AMOT Antibodies) is a direct substrate of Lats1 (show LATS1 Antibodies)/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats (show LATS1 Antibodies) genes show distinctly different expression profiles during gastrulation. lats1 (show LATS1 Antibodies) is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Pig (Porcine) LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) interaction partners

  1. The lats2 exhibit inverted expression to YAP1 (show YAP1 Antibodies), another member of the Hippo pathway which positively regulates cell growth and proliferation, during the differentiation of 3T3-L1 preadipocytes.

LATS2 Antigen Profile

Protein Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Gene names and symbols associated with LATS2

  • LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2) antibody
  • large tumor suppressor 2 (Lats2) antibody
  • large tumor suppressor kinase 2 (LATS2) antibody
  • LATS, large tumor suppressor, homolog 2 (Drosophila) (lats2) antibody
  • 4932411G09Rik antibody
  • AV277261 antibody
  • AW228608 antibody
  • KPM antibody
  • lats2 antibody

Protein level used designations for LATS2

kinase phosphorylated during mitosis protein , large tumor suppressor homolog 2 , serine/threonine-protein kinase LATS2 , serine/threonine-protein kinase kpm , large tumor suppressor, homolog 2 , LATS (large tumor suppressor, Drosophila) homolog 2 , LATS, large tumor suppressor, homolog 2 , serine/threonine kinase KPM , warts-like kinase , large tumor suppressor 2-like protein

GENE ID SPECIES
100050150 Equus caballus
50523 Mus musculus
305922 Rattus norvegicus
26524 Homo sapiens
508208 Bos taurus
567674 Danio rerio
418949 Gallus gallus
477343 Canis lupus familiaris
100415907 Sus scrofa
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