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LEM Domain Containing 3 Proteins (LEMD3)

This locus encodes a LEM domain-containing protein. Additionally we are shipping LEM Domain Containing 3 Antibodies (17) and LEM Domain Containing 3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LEMD3 23592 Q9Y2U8
Rat LEMD3 LEMD3 680066  
LEMD3 380664 Q9WU40
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Top LEM Domain Containing 3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LEMD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for LEM Domain Containing 3 (LEMD3) Interaction Partners

Pig (Porcine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 (show WIF1 Proteins) as the candidates for porcine ear size.

Human LEM Domain Containing 3 (LEMD3) interaction partners

  1. A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.

  2. Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 (show ARNTL Proteins) promoter and enhances its transcription.

  3. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A (show PPM1A Proteins).

  4. The absence of direct binding of BAF (show BANF1 Proteins) to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.

  5. Genetic analyses of three generations of a family with Buschke-Ollendorff syndrome having a variable phenotype showed a novel c.2203C>T nonsense mutation at the LEMD3 locus. The mutation induced a change in the 735 arginine codon to a stop codon.

  6. Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin (show ELN Proteins) expression.

  7. We found a novel c.2203C > T (p.R735X) mutation in exon 9 of LEMD3, resulting in a premature stop codon at amino acid position 735.

  8. Absence of LEMD3 mutation in the exons and splice sites of a family with BOS suggests that there is genetic heterogeneity for this disorder.

  9. Binds to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and antagonizes signaling by transforming growth factor-beta

  10. Overexpression results in inhibition of R-Smad (show SMAD1 Proteins) phosphorylation, heterodimerization with Smad4 (show SMAD4 Proteins), and nuclear translocation

Mouse (Murine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A (show PPM1A Proteins).

  2. the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome.

  3. In Man1-deficient embryos, the expression of Tgfb1 (show TGFB1 Proteins) is upregulated and Smad2 (show SMAD2 Proteins)/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis.

  4. The nuclear envelope protein (show SUN2 Proteins) MAN1 regulates TGFbeta (show TGFB1 Proteins) signaling and vasculogenesis in the embryonic yolk sac (show ADCY10 Proteins).

  5. Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner

LEM Domain Containing 3 (LEMD3) Protein Profile

Protein Summary

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene names and symbols associated with LEMD3

  • LEM domain containing 3 (LEMD3)
  • LEM domain containing 3 (lemd3)
  • LEM domain containing 3 (Lemd3)
  • AI316861 protein
  • im:7158446 protein
  • Man1 protein
  • RGD1561001 protein
  • sane protein
  • si:dkey-6a5.6 protein
  • wu:fb34b12 protein
  • xman1 protein

Protein level used designations for LEMD3

LEM domain containing 3 , inner nuclear membrane protein Man1 , Smad1 antagonistic effector , LEM domain-containing protein 3 , integral inner nuclear membrane protein , integral inner nuclear membrane protein MAN1

GENE ID SPECIES
417832 Gallus gallus
452050 Pan troglodytes
530659 Bos taurus
558474 Danio rerio
717597 Macaca mulatta
100038042 Xenopus (Silurana) tropicalis
100079476 Ornithorhynchus anatinus
100346960 Oryctolagus cuniculus
100402143 Callithrix jacchus
100441107 Pongo abelii
100511508 Sus scrofa
100553511 Anolis carolinensis
23592 Homo sapiens
608380 Canis lupus familiaris
680066 Rattus norvegicus
380664 Mus musculus
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