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LPHN3 encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Additionally we are shipping Latrophilin 3 Antibodies (37) and many more products for this protein.
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Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3 (show FLRT3 ELISA Kits), forming a trimeric complex, and that FLRT3 (show FLRT3 ELISA Kits) may form transsynaptic complexes with both LPHN3 and UNC5.
LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD.
Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed.
genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control.
Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer.
The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling.
A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome.
This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan.
single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 (show DRD2 ELISA Kits) and NCAM1 (show NCAM1 ELISA Kits) genes, to double the risk of developing ADHD.
This study demonistrated that LPHN3 and its ligand FLRT3 (show FLRT3 ELISA Kits) play an important role in glutamatergic synapse development.
The crystal structure of the OLF/FLRT3 (show FLRT3 ELISA Kits) complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3 (show FLRT3 ELISA Kits)-LRR with a combination of hydrophobic and charged residues.
Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation.
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.
, calcium-independent alpha-latrotoxin receptor 3
, latrophilin homolog 3 (cow)
, lectomedin 3
, calcium-independent alpha-latrotoxin receptor homolog 3