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Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) ELISA Kits

The protein encoded by LRAT is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Additionally we are shipping LRAT Antibodies (66) and LRAT Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LRAT 9227 O95237
LRAT 79235 Q9JI60
LRAT 64047 Q9JI61
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Top LRAT ELISA Kits at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 6.25 pg/ml 25-1600 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details
Rat
96 Tests Log in to see 11 to 13 Days
$875.60
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Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
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Cow
96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for LRAT Interaction Partners

Human Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens.

  2. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells.

  3. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family

  4. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis

  5. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1 (show RBP1 ELISA Kits), that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.

  6. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation.

  7. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens.

  8. Data show that acyl-modified forms of HRAS (show HRAS ELISA Kits)-like tumor suppressors HRASLS2 and HRASLS3 (show PLA2G16 ELISA Kits) mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.

  9. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy (show MERTK ELISA Kits).

  10. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis (show CISH ELISA Kits) retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions.

Cow (Bovine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

  2. LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 (show RPE65 ELISA Kits) with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

Mouse (Murine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. examined LRAT regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs

  2. LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma

  3. Mislocalized M-opsin was degraded whereas mislocalized S-opsin (show OPN1SW ELISA Kits) accumulated in Lrat(-/-) cones before the onset of massive ventral/central cone degeneration.

  4. Studies provide mechanistic insights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LRAT as a critical component of this process.

  5. Lrat KO mice exhibited increased levels of retinoic acid-responsive genes, including p21.

  6. Analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine (show SGMS2 ELISA Kits) substrates. The addition of an acyl chain occurs at the Cys (show DNAJC5 ELISA Kits)(161) residue, indicating formation of a thioester intermediate.

  7. FATP1 (show FATP1 ELISA Kits) inhibits 11-cis (show CISH ELISA Kits) retinol formation via interaction with the visual cycle retinoid isomerase RPE65 (show RPE65 ELISA Kits) and lecithin:retinol acyltransferase

  8. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

  9. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

  10. LRAT has a role in retinoid absorption and storage

LRAT Antigen Profile

Antigen Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Gene names and symbols associated with LRAT

  • lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (LRAT) antibody
  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (Lrat) antibody
  • 1300010A18Rik antibody
  • AI449251 antibody
  • LCA14 antibody

Protein level used designations for LRAT

lecithin retinol acyltransferase , phosphatidylcholine--retinol O-acyltransferase , phosphatidylcholine-retinol-O-acyltransferase , lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

GENE ID SPECIES
9227 Homo sapiens
281285 Bos taurus
79235 Mus musculus
64047 Rattus norvegicus
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