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May block the elongation and depolymerization of the actin filaments at the pointed end (By similarity).. Additionally we are shipping Leiomodin 2 Antibodies (20) and many more products for this protein.
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The mutation reduced binding affinity for both Lmod2 and Tmod1 (show TMOD1 Proteins). The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 (show TMOD1 Proteins) provides a molecular rationale for the development of familial dilated cardiomyopathies .
The C-terminal extension of Lmod2 and C terminal of Tmod1 (show TMOD1 Proteins) are sufficient to produce a filament nucleator.
Complementary functional studies suggest that the binding of Lmod2 stimulates ATP hydrolysis and accelerates actin nucleation and polymerization.
study describes an actin-binding protein (show KPTN Proteins), leiomodin, that acted as a strong filament nucleator in muscle cells
Data indicate that leiomodin 2 protein(Lmod2) functions to elongate actin filaments in the heart.
May block the elongation and depolymerization of the actin filaments at the pointed end (By similarity).