Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) ELISA Kits

LRSAM1 encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Additionally we are shipping LRSAM1 Antibodies (47) and LRSAM1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
LRSAM1 90678 Q6UWE0
LRSAM1 227738 Q80ZI6
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Top LRSAM1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
  96 Tests Log in to see 15 to 18 Days
$875.60
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for LRSAM1 Interaction Partners

Human Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated.

  2. findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery.

  3. findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1.

  4. LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination.

  5. Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

  6. disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1

  7. Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.

  8. Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.

  9. homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy

  10. LRSAM1 as a component of the antibacterial autophagic response.

Mouse (Murine) Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. TLR4 (show TLR4 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.

  2. Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.

LRSAM1 Antigen Profile

Antigen Summary

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with LRSAM1

  • leucine rich repeat and sterile alpha motif containing 1 (LRSAM1) antibody
  • leucine rich repeat and sterile alpha motif containing 1 (Lrsam1) antibody
  • CMT2P antibody
  • RIFLE antibody
  • TAL antibody

Protein level used designations for LRSAM1

E3 ubiquitin-protein ligase LRSAM1 , Tsg101-associated ligase , leucine-rich repeat and sterile alpha motif-containing protein 1 , tsg101-associated ligase

GENE ID SPECIES
90678 Homo sapiens
227738 Mus musculus
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