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Leucine-Rich, Glioma Inactivated 1 Proteins (LGI1)

LGI1 is rearranged as a result of translocations in glioblastoma cell lines. Additionally we are shipping Leucine-Rich, Glioma Inactivated 1 Antibodies (67) and Leucine-Rich, Glioma Inactivated 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LGI1 56839 Q9JIA1
LGI1 9211 O95970
LGI1 252892 Q8K4Y5
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Top Leucine-Rich, Glioma Inactivated 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,488.83
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

LGI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

More Proteins for Leucine-Rich, Glioma Inactivated 1 (LGI1) Interaction Partners

Mouse (Murine) Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. LGI1 has a role in regulating cortical development, which is increasingly becoming recognized as one of the causes of idiopathic epilepsy.

  2. LGI1 and ADAM22 (show ADAM22 Proteins) form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 (show DLG4 Proteins)

  3. Review article demonstrating that LGI1 may be an essential player in the development of the brain

  4. Glutamatergic neuron-targeted loss of Lgi1 causes a severe epileptic phenotype; Lgi1 displays an essential role in brain during the whole life.

  5. Lgi1 contains nuclear localization signal that mediates Lgi1 localization to cytoplasm and nucleus in CNS embryonic neurons.

  6. This study demonistrated that LGI1 plays a critical role in both dendritic and axonal pruning, we identify a novel molecular pathway in synapse and circuit remodeling.

  7. Lgi1 may have a role in establishing normal brain architecture and neuronal functions during brain development suggesting that it may be involved in neurogenesis and neuronal plasticity

  8. LGI1(+/-) and LGI1(-/-) mice may provide useful models for lateral temporal lobe epilepsy, and more generally idiopathic focal epilepsy.

  9. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 (show CA1 Proteins) neuronal hyperexcitability.

  10. in the brain of C57BL/6J adult mice by in situ hybridization. We found that the LGI1 transcript is mainly expressed in the dentate gyrus and CA3 (show CA3 Proteins) field of the hippocampus.

Human Leucine-Rich, Glioma Inactivated 1 (LGI1) interaction partners

  1. Clinical analysis of a lateral temporal lobe epilepsy cohort from Turkey and genetic contribution of LGI1 to autosomal dominant lateral temporal lobe epilepsy phenotype

  2. Report of three novel LGI1 mutations, a microdeletion of exon 2 and two missense mutations in exon 8, occurring in two autosomal dominant lateral temporal epilepsy families and in one sporadic patient with lateral temporal epilepsy

  3. study found no cryptic imbalances were in LGI1 in partial epilepsy with auditory features (PEAF) patients, suggesting that LGI1 microdeletions are not a frequent cause of PEAF

  4. The Multiplex ligation-dependent probe amplifications analysis did not reveal any pathogenic changes in the LGI1 gene. Chromosomal rearrangements involving the LGI1 gene were not identified in our series of familial or sporadic LTE (show SLC12A4 Proteins).

  5. A new LGI1 missense mutation is identified in a large Korean family with autosomal dominant lateral temporal lobe epilepsy.

  6. Seven LGI1-affected individuals report auditory aura (show AURKA Proteins) and one visual aura (show AURKA Proteins); three families with autosomal dominant epilepsy and auditory features have novel LGI1 mutations.

  7. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.

  8. This study expands the phenotypic spectrum associated with Autosomal dominant lateral temporal lobe epilepsy due to LGI1 mutation and underlines the need for more systematic evaluation of Attention-deficit hyperactivity disorder and related symptoms.

  9. The LGI1-ADAM22 (show ADAM22 Proteins) interaction is neutralized by autoantibodies to epilepsy-related LGI1 in limbic encephalitis.

  10. This study demonistrated that Low penetrance of autosomal dominant lateral temporal epilepsy in Italian families without LGI1 mutations.

Leucine-Rich, Glioma Inactivated 1 (LGI1) Protein Profile

Protein Summary

This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy.

Gene names and symbols associated with LGI1

  • leucine-rich, glioma inactivated 1 (LGI1)
  • leucine-rich, glioma inactivated 1 (LOC733906)
  • leucine-rich, glioma inactivated 1 (lgi1)
  • leucine-rich, glioma inactivated 1 (LOC100219007)
  • leucine-rich repeat LGI family, member 1 (Lgi1)
  • leucine-rich, glioma inactivated 1 (Lgi1)
  • ADLTE protein
  • ADPAEF protein
  • ADPEAF protein
  • BB130740 protein
  • EPITEMPIN protein
  • EPT protein
  • ETL1 protein
  • IB1099 protein
  • MGC146600 protein

Protein level used designations for LGI1

leucine-rich glioma-inactivated protein 1 , leucine-rich, glioma inactivated 1 , leucine-rich glioma-inactivated protein 1-like , epitempin-1 , polymorphic marker clone YB07 , leucine-rich repeat LGI family, member 1 , putative leucine-rich glioma inactivated 1

GENE ID SPECIES
423802 Gallus gallus
700520 Macaca mulatta
733906 Xenopus (Silurana) tropicalis
779819 Xenopus (Silurana) tropicalis
100172937 Pongo abelii
100219007 Taeniopygia guttata
100415038 Callithrix jacchus
100597927 Nomascus leucogenys
56839 Mus musculus
9211 Homo sapiens
477777 Canis lupus familiaris
617080 Bos taurus
252892 Rattus norvegicus
450619 Pan troglodytes
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