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Orphan receptor. Additionally we are shipping LGR5 Proteins (9) and LGR5 Kits (5) and many more products for this protein.
Showing 10 out of 205 products:
Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389218
Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007
Show all 11 references for 389218
Human Monoclonal LGR5 Primary Antibody for FACS, IF - ABIN2454875
Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013
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Human Polyclonal LGR5 Primary Antibody for EIA, IHC (p) - ABIN357894
Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. in Hepatology (Baltimore, Md.) 2003
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Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389215
Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010
Show all 4 references for 389215
Human Polyclonal LGR5 Primary Antibody for IHC, IHC (fro) - ABIN440586
Jung, Saif: Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. in Veterinary journal (London, England : 1997) 2015
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Human Polyclonal LGR5 Primary Antibody for FACS, IHC (p) - ABIN389219
Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011
Show all 3 references for 389219
Human Polyclonal LGR5 Primary Antibody for EIA, FACS - ABIN357893
McClanahan, Koseoglu, Smith, Grein, Gustafson, Black, Kirschmeier, Samatar: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. in Cancer biology & therapy 2006
Show all 2 references for 357893
Human Polyclonal LGR5 Primary Antibody for IHC (p) - ABIN4330855
Chen, Chen, Chien, Wu, Ho, Yu, Chang: Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury. in PLoS ONE 2015
Human Polyclonal LGR5 Primary Antibody for IF (p), IHC (p) - ABIN737916
Su, Li, Liu, Ren, Tian, Liu, Qiu: Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype. in Oncology reports 2016
Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.
Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.
role for Lgr5(+) cancer stem cells in primary and metastatic colon cancer
Data show that both the number and relative position of Paneth cells and Lgr5+ cells are important for fission.
RSPO (show RSPO1 Antibodies)-LGR4 (show LGR4 Antibodies)/5-ZNRF3 (show ZNRF3 Antibodies)/RNF43 (show RNF43 Antibodies) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
adult stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is expressed in the mice nasal respiratory epithelium.
Employing Lgr5-lacZ (show GLB1 Antibodies) transgenic mice and Lgr5 in situ hybridization, authors found colonic epithelial stem cells (CESC) markedly more radioresistant in vivo than small intestinal crypt base columnar stem cells.
Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.
Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.
Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.
LGR5-expressing fraction of CD54 (show ICAM1 Antibodies)+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT (show ITK Antibodies) core genes
clathrin-mediated endocytosis inhibition of the leucine-rich G protein-coupled receptor-5 (show XCR1 Antibodies) diminishes cell fitness
The findings indicated that Lgr5 might contribute to the intestinal metaplasia during gastric carcinogenesis.
Endometrial LGR5 is not an endogenous stem cell marker. Instead, LGR5(+) cells appear to be recruited from blood to be part of the stem cell niche at the perivascular microenvironment to activate the endogenous niche.
2 LGR5 splice variants were expressed in human intestine crypt cells; one lacked exon 5 and the other lacked exons 5-8. Only LGR5FL appeared during cell cycle arrest. The transcript variants appeared when the cell cycle was proceeding. LGR5FL-positive cells were negative for Ki-67 (show MKI67 Antibodies) and were enriched after chemotherapy.
Low expression of LGR5 is associated with gastric cancer.
High LGR5 expression is associated with colorectal cancer.
Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
leucine-rich repeat-containing G protein-coupled receptor 5
, leucine-rich repeat-containing G-protein coupled receptor 5A
, leucine-rich repeat-containing G-protein coupled receptor 5a
, G protein-coupled receptor 49
, G-protein coupled receptor 49
, follicle expressed hormone
, leucine-rich repeat-containing G-protein coupled receptor 5
, orphan G-protein coupled receptor FEX
, G-protein coupled receptor 67
, G-protein coupled receptor HG38
, orphan G protein-coupled receptor HG38