anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibodies

Orphan receptor. Additionally we are shipping LGR5 Proteins (9) and LGR5 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
LGR5 299802  
LGR5 8549 O75473
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Top anti-LGR5 Antibodies at antibodies-online.com

Showing 10 out of 205 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of anti-LGR5/GPR49 Antibody (Center) (ABIN389219) in K562 cell line lysates (35 µg/lane). LGR5/GPR49(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (Center) (ABIN389219), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Anti-LGR5 mouse monoclonal antibody ABIN2454875 immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5 (RC212845). HEK293T cells were transfected with the empty vector control (Left lane) or Human LGR5 expression plasmid (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR5. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (N-term) (ABIN389215) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (N-term) (ABIN389215), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (loop1) (ABIN389217), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. LGR5/GPR49 Antibody (loop1) (ABIN389217) western blot analysis in HL-60 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (Loop2) (ABIN389218) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Western blot analysis of anti-LGR5/GPR49 Antibody (loop2) (ABIN389218) in mouse cerebellum tissue lysates (35 µg/lane).LGR5/GPR49(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded mouse colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Frozen: Lgr5/GPR49 Antibody [NBP1-28904] - Staining on pig small intestine from a review by a confirmed customer. 0.1 mL Log in to see 7 to 9 Days
$473.81
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human colon. Immunohistochemistry-Paraffin: Lgr5/GPR49 Antibody [NLS1236] - Analysis of anti-GPR49 antibody with human, small intestine. 0.05 mL Log in to see 7 to 9 Days
$447.56
Details

LGR5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LGR5 Antibodies

  1. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389218 : Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007 (PubMed)
    Show all 11 references for 389218

  2. Human Monoclonal LGR5 Primary Antibody for FACS, IF - ABIN2454875 : Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013 (PubMed)
    Show all 7 references for 2454875

  3. Human Polyclonal LGR5 Primary Antibody for EIA, IHC (p) - ABIN357894 : Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. in Hepatology (Baltimore, Md.) 2003 (PubMed)
    Show all 4 references for 357894

  4. Human Polyclonal LGR5 Primary Antibody for FACS, IF - ABIN389215 : Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010 (PubMed)
    Show all 4 references for 389215

  5. Human Polyclonal LGR5 Primary Antibody for IHC, IHC (fro) - ABIN440586 : Jung, Saif: Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. in Veterinary journal (London, England : 1997) 2015 (PubMed)
    Show all 3 references for 440586

  6. Human Polyclonal LGR5 Primary Antibody for FACS, IHC (p) - ABIN389219 : Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011 (PubMed)
    Show all 3 references for 389219

  7. Human Polyclonal LGR5 Primary Antibody for EIA, FACS - ABIN357893 : McClanahan, Koseoglu, Smith, Grein, Gustafson, Black, Kirschmeier, Samatar: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. in Cancer biology & therapy 2006 (PubMed)
    Show all 2 references for 357893

  8. Human Polyclonal LGR5 Primary Antibody for IHC (p) - ABIN4330855 : Chen, Chen, Chien, Wu, Ho, Yu, Chang: Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury. in PLoS ONE 2015 (PubMed)

  9. Human Polyclonal LGR5 Primary Antibody for IF (p), IHC (p) - ABIN737916 : Su, Li, Liu, Ren, Tian, Liu, Qiu: Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype. in Oncology reports 2016 (PubMed)

More Antibodies against LGR5 Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  2. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.

  3. role for Lgr5(+) cancer stem cells in primary and metastatic colon cancer

  4. Data show that both the number and relative position of Paneth cells and Lgr5+ cells are important for fission.

  5. RSPO (show RSPO1 Antibodies)-LGR4 (show LGR4 Antibodies)/5-ZNRF3 (show ZNRF3 Antibodies)/RNF43 (show RNF43 Antibodies) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  6. adult stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is expressed in the mice nasal respiratory epithelium.

  7. Employing Lgr5-lacZ (show GLB1 Antibodies) transgenic mice and Lgr5 in situ hybridization, authors found colonic epithelial stem cells (CESC) markedly more radioresistant in vivo than small intestinal crypt base columnar stem cells.

  8. Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.

  9. Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.

  10. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  2. LGR5-expressing fraction of CD54 (show ICAM1 Antibodies)+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT (show ITK Antibodies) core genes

  3. clathrin-mediated endocytosis inhibition of the leucine-rich G protein-coupled receptor-5 (show XCR1 Antibodies) diminishes cell fitness

  4. The findings indicated that Lgr5 might contribute to the intestinal metaplasia during gastric carcinogenesis.

  5. Endometrial LGR5 is not an endogenous stem cell marker. Instead, LGR5(+) cells appear to be recruited from blood to be part of the stem cell niche at the perivascular microenvironment to activate the endogenous niche.

  6. 2 LGR5 splice variants were expressed in human intestine crypt cells; one lacked exon 5 and the other lacked exons 5-8. Only LGR5FL appeared during cell cycle arrest. The transcript variants appeared when the cell cycle was proceeding. LGR5FL-positive cells were negative for Ki-67 (show MKI67 Antibodies) and were enriched after chemotherapy.

  7. Low expression of LGR5 is associated with gastric cancer.

  8. High LGR5 expression is associated with colorectal cancer.

  9. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  10. Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage

LGR5 Antigen Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 (lgr5) antibody
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5) antibody
  • leucine-rich repeat containing G protein-coupled receptor 5 (LGR5) antibody
  • FEX antibody
  • GPR49 antibody
  • GPR67 antibody
  • GRP49 antibody
  • HG38 antibody
  • lgr5-a antibody
  • lgr5a antibody

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
Selected quality suppliers for anti-LGR5 (LGR5) Antibodies
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