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Like-Glycosyltransferase Proteins (LARGE)

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Additionally we are shipping Like-Glycosyltransferase Antibodies (31) and Like-Glycosyltransferase Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
Rat LARGE LARGE 361368  
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Top Like-Glycosyltransferase Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

LARGE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Like-Glycosyltransferase (LARGE) Interaction Partners

Human Like-Glycosyltransferase (LARGE) interaction partners

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (show SERPINC1 Proteins).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extracellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase (show GTDC2 Proteins), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 Proteins) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (show TRH Proteins)-317 and -319, within the highly conserved first 18 amino acids of the mucin (show SLC13A2 Proteins)-like domain

  5. LARGE2 (show GYLTL1B Proteins) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) interaction partners

  1. MBP1 (show ENO1 Proteins) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (show ENO1 Proteins) to reduce Ab pathology and improve behavioral performance.

  2. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (show IGF1 Proteins).

  3. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (show GYLTL1B Proteins) required for functional modification of alpha-dystroglycan in cells and tissues.

  4. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (show FKRP Proteins)-MD phenotype

  5. blocking Large during muscle regeneration results in synthesis of dystroglycan with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  6. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan in stabilizing the endplate of the neuromuscular junction.

  7. LARGE could act as a bifunctional glycosyltransferase (show GTDC2 Proteins), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 Proteins) ligands

  8. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  9. a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG

  10. Previously unreported ocular defects in mice homozygous for a new allele of the Large gene, veils, and for Large(myd) mice.

Like-Glycosyltransferase (LARGE) Protein Profile

Protein Summary

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene names and symbols associated with LARGE

  • like-glycosyltransferase (LARGE)
  • like-glycosyltransferase (large)
  • glycosyltransferase-like 1B (GYLTL1B)
  • like-glycosyltransferase (Large)
  • BPFD36 protein
  • DKFZp459G0120 protein
  • enr protein
  • fg protein
  • froggy protein
  • Gyltl1a protein
  • gyltl1b protein
  • gyltl1b-b protein
  • LARGE protein
  • Mbp-1 protein
  • Mbp1 protein
  • mdc1d protein
  • MDDGA6 protein
  • MDDGB6 protein
  • mKIAA0609 protein
  • myd protein
  • NV15834 protein

Protein level used designations for LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPECIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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