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Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Additionally we are shipping Lin-28 Homolog A (C. Elegans) Proteins (19) and Lin-28 Homolog A (C. Elegans) Kits (17) and many more products for this protein.
Showing 10 out of 167 products:
Human Monoclonal LIN28A Primary Antibody for IF, IHC (p) - ABIN387790
Peng, Maihle, Huang: Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. in Oncogene 2010
Show all 5 references for ABIN387790
Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953173
Qiu, Ma, Wang, Peng, Huang: Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. in Nucleic acids research 2010
Show all 5 references for ABIN953173
Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953174
Iliopoulos, Hirsch, Struhl: An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. in Cell 2009
Show all 5 references for ABIN953174
Mouse (Murine) Polyclonal LIN28A Primary Antibody for FACS, IF - ABIN655156
Heo, Joo, Kim, Ha, Yoon, Cho, Yeom, Han, Kim: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. in Cell 2009
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Human Polyclonal LIN28A Primary Antibody for FACS, WB - ABIN655496
West, Viswanathan, Yabuuchi, Cunniff, Takeuchi, Park, Sero, Zhu, Perez-Atayde, Frazier, Surani, Daley: A role for Lin28 in primordial germ-cell development and germ-cell malignancy. in Nature 2009
Show all 5 references for ABIN655496
Human Polyclonal LIN28A Primary Antibody for WB - ABIN783322
Heo, Joo, Cho, Ha, Han, Kim: Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. in Molecular cell 2008
Show all 3 references for ABIN783322
Human Monoclonal LIN28A Primary Antibody for ICC, ELISA - ABIN968936
Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2005
Show all 2 references for ABIN968936
Human Polyclonal LIN28A Primary Antibody for EIA, IHC (p) - ABIN500176
Ambros: A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. in Cell 1989
Cow (Bovine) Polyclonal LIN28A Primary Antibody for IHC, WB - ABIN2775818
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Lin28A is up-regulated in 73.3 % of colon cancer patients. Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting apoptosis in a let-7 independent manner, associated with decreasing the expression of DNA damage repair protein H2AX.
Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 Antibodies) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 expression.
Data suggest that the Lin28/let-7 (lin-28 homolog protein/mirnlet7 microRNA) molecular switch plays roles in regulation of cell growth signaling pathways and in regulation of expression of metabolic enzymes. [REVIEW]
Lin28A expression promotes metabolic switching to a phenotype that relies predominantly on glycolysis as an energy source, while compromising oxidative phosphorylation.
high LIN28 expressing ovarian cancer cells secrete exosomes that can be taken up by nontumor cells and cause changes in gene expression and cell behavior associated with tumor development. IGROV1
data document the expression profiles of the Lin28/let-7 system in rat testis along postnatal/pubertal maturation, and their perturbation in models of pubertal and hormonal manipulation
The role of Lin28 in cancer and immunity. [Review]
Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.
Our findings suggest that Lin28 plays a key role in the acquisition of resistance to AR-targeted therapies by prostate cancer cells and establish the importance of Lin28 in prostate cancer progression.
LIN28 may regulate splicing and gene expression programs that drive breast cancer subtype phenotypes.
Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.
data point toward a complex system of regulation by Lin28a, Lin28b (show LIN28B Antibodies), and let-7, in which Lin28b (show LIN28B Antibodies) and let-7 can impact both puberty and growth in a sex-specific manner
Lin28A binds active promoters and recruits Tet1 (show TET1 Antibodies) to regulate gene expression via epigenetic DNA modifications.
Lin28a protects against DCM through PKA/ROCK2 (show ROCK2 Antibodies) dependent pathway.
Lin28B (show LIN28B Antibodies) upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development
Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin (show INS Antibodies)-PI3K-mTOR (show FRAP1 Antibodies) pathway.
Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions
Lin28a overexpression efficiently and specifically reduces let-7 miRNAs and up-regulates let-7 target genes.
Lin28 binds to guanine-rich miRNAs and mRNAs that contain G-quartet structural features and remodels these structures.
Lin28a and Lin28b (show LIN28B Antibodies) have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.
LIN28 accelerates tumor formation and enhances proliferation and invasiveness.
The knockdown of Lin-28a or Lin-28b (show LIN28B Antibodies) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.
The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
, protein lin-28 homolog A
, lin-28 homolog
, RNA-binding protein LIN-28
, lin-28 homolog A (C. elegans)
, RNA-binding protein LIN-28A
, zinc finger CCHC domain-containing protein 1
, zinc finger, CCHC domain containing 1
, testis expressed gene 17
, testis-expressed protein 17
, RNA-binding protein lin-28