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anti-Lin-28 Homolog A (C. Elegans) (LIN28A) Antibodies

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Additionally we are shipping Lin-28 Homolog A (C. Elegans) Proteins (21) and Lin-28 Homolog A (C. Elegans) Kits (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LIN28A 298542  
LIN28A 79727 Q9H9Z2
LIN28A 83557 Q8K3Y3
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Top anti-Lin-28 Homolog A (C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 146 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-LIN28 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts from HepG2 cells using Lin28. 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated DB, IF Dot blot analysis of anti-Phospho-LIN28-S134 Phospho-specific Pab (ABIN650868) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated FACS, IF, IHC (p), WB LIN28A Antibody (Center)  western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the LIN28A antibody detected the LIN28A protein (arrow). Fluorescent confocal image of SY5Y cells stained with AP11206c LIN28A (Center) antibody. SY5Y cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min), then incubated with AP11206c LIN28A (Center) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (5.25 μM, 25 min). Lin28a immunoreactivity is localized very specifically to the nuclei of the SY5Y cells. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB LIN28 Antibody  western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the LIN28 antibody detected the LIN28 protein (arrow). LIN28 Antibody  western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the LIN28 antibody detected the LIN28 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of Hela cells using LIN28A Antibody (Center) Cat.-No AP52487PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue reacted with LIN28A Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, IHC (p), WB Western blot analysis of LIN28 recombinant protein by anti-LIN28A Monoclonal Antibody (ABIN387790). LIN28 (arrow) was detected using the purified Mab. Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28A Monoclonal Antibody (ABIN387790), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of MDA-MB435 cells using  LIN28 Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of  LIN28 Antibody  in mouse Neuro-2a cell line lysates (35ug/lane). This demonstrates the LIN28 antibody detected the LIN28 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of KLF4 in human spleen tissue AP30509PU-N antibody at 5 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Confocal immunofluorescence analysis of methanol fixed Hela cells were transfected with pMX construct of human LIN28, cells were analyzed ~62 hours after transfection. Figure 2: Confocal immunofluorescence analysis of NTERA-2 cells using LIN28 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. 100 μL Log in to see 3 to 4 Days
$442.20
Details

LIN28A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Lin-28 Homolog A (C. Elegans) Antibodies

  1. Human Monoclonal LIN28A Primary Antibody for IF, IHC (p) - ABIN387790 : Peng, Maihle, Huang: Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. in Oncogene 2010 (PubMed)
    Show all 5 references for ABIN387790

  2. Human Polyclonal LIN28A Primary Antibody for FACS, WB - ABIN655496 : Qiu, Ma, Wang, Peng, Huang: Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. in Nucleic acids research 2010 (PubMed)
    Show all 5 references for ABIN655496

  3. Mouse (Murine) Polyclonal LIN28A Primary Antibody for FACS, IF - ABIN655156 : Iliopoulos, Hirsch, Struhl: An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. in Cell 2009 (PubMed)
    Show all 5 references for ABIN655156

  4. Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953173 : West, Viswanathan, Yabuuchi, Cunniff, Takeuchi, Park, Sero, Zhu, Perez-Atayde, Frazier, Surani, Daley: A role for Lin28 in primordial germ-cell development and germ-cell malignancy. in Nature 2009 (PubMed)
    Show all 5 references for ABIN953173

  5. Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953174 : Heo, Joo, Kim, Ha, Yoon, Cho, Yeom, Han, Kim: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. in Cell 2009 (PubMed)
    Show all 5 references for ABIN953174

  6. Human Polyclonal LIN28A Primary Antibody for WB - ABIN783322 : Heo, Joo, Cho, Ha, Han, Kim: Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. in Molecular cell 2008 (PubMed)
    Show all 3 references for ABIN783322

  7. Human Monoclonal LIN28A Primary Antibody for ICC, ELISA - ABIN968936 : Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2005 (PubMed)
    Show all 2 references for ABIN968936

  8. Human Polyclonal LIN28A Primary Antibody for EIA, IHC (p) - ABIN500176 : Ambros: A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. in Cell 1989 (PubMed)

  9. Cow (Bovine) Polyclonal LIN28A Primary Antibody for IHC, WB - ABIN2775818 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

More Antibodies against Lin-28 Homolog A (C. Elegans) Interaction Partners

Human Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. high LIN28 expressing ovarian cancer cells secrete exosomes that can be taken up by nontumor cells and cause changes in gene expression and cell behavior associated with tumor development. IGROV1

  2. data document the expression profiles of the Lin28/let-7 system in rat testis along postnatal/pubertal maturation, and their perturbation in models of pubertal and hormonal manipulation

  3. The role of Lin28 in cancer and immunity. [Review]

  4. Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

  5. Our findings suggest that Lin28 plays a key role in the acquisition of resistance to AR-targeted therapies by prostate cancer cells and establish the importance of Lin28 in prostate cancer progression.

  6. LIN28 may regulate splicing and gene expression programs that drive breast cancer subtype phenotypes.

  7. Data implicate LIN28/RAS/MAP kinase (show MAPK1 Antibodies) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.

  8. LIN28 and its regulatory microRNAs have roles in adult adrenocortical cancer

  9. LIN28A over-expression increased HbF, reduced beta (sickle)-globin, and strongly suppressed all members of the let-7 family of miRNAs while reducing erythrocyte sickling.

  10. Lin28A and Lin28B (show LIN28B Antibodies) enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1 (show PDK1 Antibodies), or PDK1 (show PDK1 Antibodies).

Cow (Bovine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.

Mouse (Murine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. data point toward a complex system of regulation by Lin28a, Lin28b (show LIN28B Antibodies), and let-7, in which Lin28b (show LIN28B Antibodies) and let-7 can impact both puberty and growth in a sex-specific manner

  2. Lin28A binds active promoters and recruits Tet1 (show TET1 Antibodies) to regulate gene expression via epigenetic DNA modifications.

  3. Lin28a protects against DCM through PKA/ROCK2 (show ROCK2 Antibodies) dependent pathway.

  4. Lin28B (show LIN28B Antibodies) upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development

  5. Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin (show INS Antibodies)-PI3K-mTOR (show FRAP1 Antibodies) pathway.

  6. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions

  7. Lin28a overexpression efficiently and specifically reduces let-7 miRNAs and up-regulates let-7 target genes.

  8. Lin28 binds to guanine-rich miRNAs and mRNAs that contain G-quartet structural features and remodels these structures.

  9. Lin28a and Lin28b (show LIN28B Antibodies) have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  10. LIN28 accelerates tumor formation and enhances proliferation and invasiveness.

Zebrafish Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. The knockdown of Lin-28a or Lin-28b (show LIN28B Antibodies) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.

  2. The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.

Lin-28 Homolog A (C. Elegans) (LIN28A) Antigen Profile

Protein Summary

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

Gene names and symbols associated with LIN28A

  • lin-28 homolog C (C. elegans) (Lin28c) antibody
  • lin-28 homolog A (lin28a) antibody
  • lin-28 homolog (C. elegans) (lin28) antibody
  • RNA-binding protein LIN-28 (lin28) antibody
  • lin-28 homolog A (C. elegans) (LIN28A) antibody
  • lin-28 homolog A (C. elegans) (Lin28a) antibody
  • lin-28 homolog A (C. elegans) (lin28a) antibody
  • AL024421 antibody
  • CSDD1 antibody
  • ENSMUSG00000070700 antibody
  • Gm10299 antibody
  • Lin-28 antibody
  • lin-28A antibody
  • LIN28 antibody
  • RGD1566408 antibody
  • sb:cb650 antibody
  • Tex17 antibody
  • ZCCHC1 antibody
  • zgc:55584 antibody

Protein level used designations for LIN28A

lin-28A , protein lin-28 homolog A , lin-28 homolog , RNA-binding protein LIN-28 , lin-28 homolog A (C. elegans) , lin-28-like , RNA-binding protein LIN-28A , zinc finger CCHC domain-containing protein 1 , zinc finger, CCHC domain containing 1 , testis expressed gene 17 , testis-expressed protein 17 , Lin-28.1 , RNA-binding protein lin-28

GENE ID SPECIES
298542 Rattus norvegicus
548523 Xenopus (Silurana) tropicalis
549020 Xenopus (Silurana) tropicalis
100012320 Monodelphis domestica
100071098 Equus caballus
100302344 Ovis aries
100379627 Felis catus
387262 Xenopus laevis
79727 Homo sapiens
612162 Canis lupus familiaris
100142662 Sus scrofa
614997 Bos taurus
83557 Mus musculus
500562 Rattus norvegicus
456661 Pan troglodytes
428206 Gallus gallus
394066 Danio rerio
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