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Lin-28 Homolog A (C. Elegans) Proteins (LIN28A)

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Additionally we are shipping Lin-28 Homolog A (C. Elegans) Antibodies (145) and Lin-28 Homolog A (C. Elegans) Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LIN28A 298542  
LIN28A 79727 Q9H9Z2
LIN28A 83557 Q8K3Y3
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Top Lin-28 Homolog A (C. Elegans) Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human TAT tag   100 μg Log in to see 2 to 3 Days
$745.50
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,469.50
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,469.50
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,491.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,491.50
Details
HOST_Escherichia coli (E. coli) Human TAT tag   0.005 mg Log in to see 2 to 3 Days
$178.75
Details

LIN28A Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)
Human , ,
, ,
Mouse (Murine)

Top referenced Lin-28 Homolog A (C. Elegans) Proteins

  1. Human LIN28A Protein expressed in Escherichia coli (E. coli) - ABIN667750 : Heo, Joo, Kim, Ha, Yoon, Cho, Yeom, Han, Kim: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. in Cell 2009 (PubMed)
    Show all 2 references for ABIN667750

More Proteins for Lin-28 Homolog A (C. Elegans) (LIN28A) Interaction Partners

Human Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. high LIN28 expressing ovarian cancer cells secrete exosomes that can be taken up by nontumor cells and cause changes in gene expression and cell behavior associated with tumor development. IGROV1

  2. data document the expression profiles of the Lin28/let-7 system in rat testis along postnatal/pubertal maturation, and their perturbation in models of pubertal and hormonal manipulation

  3. The role of Lin28 in cancer and immunity. [Review]

  4. Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

  5. Our findings suggest that Lin28 plays a key role in the acquisition of resistance to AR-targeted therapies by prostate cancer cells and establish the importance of Lin28 in prostate cancer progression.

  6. LIN28 may regulate splicing and gene expression programs that drive breast cancer subtype phenotypes.

  7. Data implicate LIN28/RAS/MAP kinase (show MAPK1 Proteins) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.

  8. LIN28 and its regulatory microRNAs have roles in adult adrenocortical cancer

  9. LIN28A over-expression increased HbF, reduced beta (sickle)-globin, and strongly suppressed all members of the let-7 family of miRNAs while reducing erythrocyte sickling.

  10. Lin28A and Lin28B (show LIN28B Proteins) enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1 (show PDK1 Proteins), or PDK1 (show PDK1 Proteins).

Cow (Bovine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.

Mouse (Murine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. data point toward a complex system of regulation by Lin28a, Lin28b (show LIN28B Proteins), and let-7, in which Lin28b (show LIN28B Proteins) and let-7 can impact both puberty and growth in a sex-specific manner

  2. Lin28A binds active promoters and recruits Tet1 (show TET1 Proteins) to regulate gene expression via epigenetic DNA modifications.

  3. Lin28a protects against DCM through PKA/ROCK2 (show ROCK2 Proteins) dependent pathway.

  4. Lin28B (show LIN28B Proteins) upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development

  5. Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin (show INS Proteins)-PI3K-mTOR (show FRAP1 Proteins) pathway.

  6. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions

  7. Lin28a overexpression efficiently and specifically reduces let-7 miRNAs and up-regulates let-7 target genes.

  8. Lin28 binds to guanine-rich miRNAs and mRNAs that contain G-quartet structural features and remodels these structures.

  9. Lin28a and Lin28b (show LIN28B Proteins) have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  10. LIN28 accelerates tumor formation and enhances proliferation and invasiveness.

Zebrafish Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. The knockdown of Lin-28a or Lin-28b (show LIN28B Proteins) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.

  2. The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.

Lin-28 Homolog A (C. Elegans) (LIN28A) Protein Profile

Protein Summary

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

Gene names and symbols associated with LIN28A

  • lin-28 homolog C (C. elegans) (Lin28c)
  • lin-28 homolog A (lin28a)
  • lin-28 homolog (C. elegans) (lin28)
  • RNA-binding protein LIN-28 (lin28)
  • lin-28 homolog A (C. elegans) (LIN28A)
  • lin-28 homolog A (C. elegans) (Lin28a)
  • lin-28 homolog A (C. elegans) (lin28a)
  • AL024421 protein
  • CSDD1 protein
  • ENSMUSG00000070700 protein
  • Gm10299 protein
  • Lin-28 protein
  • lin-28A protein
  • LIN28 protein
  • RGD1566408 protein
  • sb:cb650 protein
  • Tex17 protein
  • ZCCHC1 protein
  • zgc:55584 protein

Protein level used designations for LIN28A

lin-28A , protein lin-28 homolog A , lin-28 homolog , RNA-binding protein LIN-28 , lin-28 homolog A (C. elegans) , lin-28-like , RNA-binding protein LIN-28A , zinc finger CCHC domain-containing protein 1 , zinc finger, CCHC domain containing 1 , testis expressed gene 17 , testis-expressed protein 17 , Lin-28.1 , RNA-binding protein lin-28

GENE ID SPECIES
298542 Rattus norvegicus
548523 Xenopus (Silurana) tropicalis
549020 Xenopus (Silurana) tropicalis
100012320 Monodelphis domestica
100071098 Equus caballus
100302344 Ovis aries
100379627 Felis catus
387262 Xenopus laevis
79727 Homo sapiens
612162 Canis lupus familiaris
100142662 Sus scrofa
614997 Bos taurus
83557 Mus musculus
500562 Rattus norvegicus
456661 Pan troglodytes
428206 Gallus gallus
394066 Danio rerio
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